特殊人群血清抗-HCV检测及甲、乙、丙型肝炎重复感染分析

目的 阐明特殊人群甲、乙、丙型肝炎病毒重复感染状况。 方法 采用ELISA法对4587例血清进行抗-HAV-IgM,HBsAg,抗-HBs,HBeAg,抗-HBe,抗-HBc,抗-HBcIgM及抗-HCV病毒标记检测。 结果 抗-HCV总阳性率为22.5％。献血员为23.1％,PTH为58.3％,AVH为4.7％,CPH为8.9％,CAH15.3％,SHF59.5％,CHF57.1％,LC22.9％和HCC31.8％;反复接受输血的血液病、尿毒症和血液透析患者阳性率分别为46.4％,23.8％和35.3％;性病为10.7％。668例肝病中HC重复感染HB阳性率为12.9％,且随肝损害程度而增高。 结论 HCV重复感染HBV,会加重肝损害,促使病情加剧。输血、使用血制品和血液透析术,是感染HCV的主要途径。

Investigation on HBV - HCV superinfection in particular disease populations

AIM To demonstrate the state of HBV and HCV superinfection in particular populations.METHODS The HAV, HBV and HCV markers were detected in 4587 serum samples. Anti - HAVIgM, HBsAg, Anti - HBs, HBeAg, Anti -HBe, Anti - HBc, Anti - HBcIgM and Anti - HCV were tested by ELISA.RESULTS The total positivity rate of anti - HCV was 22. 5% ; in blood donor, 23.1%; in PTH, 58.3%; in AVH, 4.7%; in CPH, 8.9%; in CAH, 15.3%; in SHF, 59.5%; in CHF, 57.1%; in LC, 22.9% and in HCC, 31.8%. The positivity rate in patients with hematonosis, uremia, hemodialysis with repeated blood transfusion were 46.4%, 23.8% and 35.3% respectively, and in STD, 10.7%. The HBV- HCV superinfection rate in 668 patients with hepatic disease was 12.9% and higher with the degree of hepatic damage.CONCLUSION HBV and HCV superinfection exacerbates hepatic damage and promote hepatic failure. Blood transfusion, administration of blood products and hemodialysis are the major ways of HCV infection.