| 脂质体携载前列腺素E_1与牛磺酸溶栓辅佐治疗的实验研究 |
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| 引用本文： | 李夏,张灵芝,龚永生,唐朝枢. 脂质体携载前列腺素E_1与牛磺酸溶栓辅佐治疗的实验研究[J]. 中国药理学通报, 1998, 0(3) |
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| 作者姓名： | 李夏 张灵芝 龚永生 唐朝枢 |
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| 作者单位： | 山西职工医学院病理生理学教研室 |
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| 摘 要： | 目的观察脂质体携载前列腺素Ｅ１（ｐｒｏｓｔａｇｌａｎｄｉｎＥ１，ＰＧＥ１）和牛磺酸作为溶栓辅佐剂的作用。方法在大鼠腹主动脉血栓模型和离体血小板上，使用脂质体携载ＰＧＥ１与牛磺酸作为尿激酶溶栓的辅助治疗。结果与单纯尿激酶比较，脂质体携载ＰＧＥ１和牛磺酸联用尿激酶，缩短了尿激酶溶栓时间，增加了血管再通后血流量，在体外降低ＡＤＰ诱导的血小板聚集。结论脂质体携载ＰＧＥ１和牛磺酸作为溶栓辅助剂可能具有良好的应用前景
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| 关 键 词： | 脂质体；前列腺素；牛磺酸；溶栓治疗 |
Studies on liposome encapsulated prostaglandin E1and taurine as a thrombolysis adjuvant therapy |
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| Abstract: | AIM To observe the effect of liposome encapsulated prostaglandin E1 and taurine (Ls PGE1 T) as a thrombolysis adjuvant. METHODS Thrombolytic effect of Ls PGE1 T with urokinase (UK) was investigated in the rat model of abdominal aorta thrombosis and in vitro blood platelet. RESULTS Ls PGE1 T together with UK shortened thrombolysis time, increased blood flow and decreased platelet aggragation induced by ADP in comparison with UK alone. CONCLUSION The results demonstrate the potential feasibility of Ls PGE1 T as a thrombolysis adjuvant. |
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| Keywords: | liposome prostaglandin tauine thrombolysis therapy |
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