粒细胞集落刺激因子治疗甲亢药物诱发粒缺评价

目的：比较糖皮质激素，粒细胞集落刺激因子（GM－CSF）及二者联合应用3种治疗方法对甲亢药物治疗诱发粒缺的疗效。方法：根据治疗方法分组，比较病例的临床指标。结果：3组病情轻重不同，各组治疗前后WBC比较差异有显著性（P＜0．05）。3组间年龄，性别，甲亢病程，服药时间，入院前出现WBC下降或感染状时间，治疗后WBC值，WBC恢复时间和体温正常时间比较差异无显著性。结论：重症病例应用GM－CSF或联合糖皮质激素治疗方案可能优于单纯糖皮质激素治疗。

Evaluation of using granulocyte colony-stimulating factor in treating agranulocytosis incorporated with antithyroid agents

Objective To evaluate effects of three kinds of treatments in agranulocytosis incorporated with antithyroid agents which consisted of corticosteroids, granulocyte colony-stimulating factor(G-CSF) and combination of two ways. Methods Reviewing cases of agranulocytosis incorporated with antithyroid agents wh ich hospitalized in recent 5 years. Dividing patients into three g roups in terms of therapy. The index consisted of age, sex, duration of hyperthyroidism, taking antithyroid drugs, occurrence of symptoms or depressing WBC count before hospitalization, recovery of WBC count and temperature after hospitalization were compared in three groups. Results The states of three groups were different. There was significant difference in WBC count comparison between before and after therapy in each group. The WBC count before therapy of group A was more than that of group B significantly. There was not significant difference in other index such as age, sex, duration of hyperthyroidism, taking antithyroid agents, occurrence of symptoms or depressing WBC count before hospitalization, recovery of WBC count and temperature after hospitalization among three groups. Conclusion Three kinds of therapy can increase WBC count efficiently, but in critical cases using G-CSF or combination with corticosteroids may be superior to using single corticosteroids. In ser ious infection case, treatment with G-CSF combination with orticosteroids may be suitable while using antibiotics.