| 新化合物O325H的抗糖尿病作用 |
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| 引用本文： | 徐成,王莉莉,龙隆,覃丹,曹颖林,李松.新化合物O325H的抗糖尿病作用[J].沈阳药科大学学报,2007,24(1):40-44. |
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| 作者姓名： | 徐成 王莉莉 龙隆 覃丹 曹颖林 李松 |
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| 作者单位： | 1. 沈阳药科大学,药学院,辽宁,沈阳,110016
2. 军事医学科学院,毒物药物研究所,北京,100850 |
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| 基金项目： | 国家高技术研究发展计划(863计划);北京市科技计划 |
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| 摘 要： | 目的研究新化合物O325H对2型糖尿病的作用。方法灌胃给药,观察O325H对正常小鼠的糖耐量以及对两种2型糖尿病小鼠的降糖降脂作用。采用RT PCR方法,研究O325H的作用机制。结果O325H对正常小鼠的糖耐量没有明显影响,对2型糖尿病小鼠有明显的降糖降脂作用,同时能够增加不同组织中脂蛋白脂酶(LPL)、脂肪酸转运蛋白(aP2)和葡萄糖转运体4(GluT4)mRNA的表达。结论O325H具有良好的降糖降脂作用,其作用机制符合PPARα/γ双重激动剂的特点,具有成为预防和治疗2型糖尿病药物的潜力。
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| 关 键 词： | O325H 2型糖尿病 过氧化物增生活性受体 |
| 文章编号： | 1006-2858(2007)01-0040-05 |
| 修稿时间： | 2006-02-21 |
Effects of the novel compound O325H on glucose and lipid metabolism |
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| XU Cheng,WANG Li-li,LONG Long,QIN Dan,CAO Ying-lin,LI Song.Effects of the novel compound O325H on glucose and lipid metabolism[J].Journal of Shenyang Pharmaceutical University,2007,24(1):40-44. |
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| Authors: | XU Cheng WANG Li-li LONG Long QIN Dan CAO Ying-lin LI Song |
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| Institution: | 1. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China ; 2. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Bejiing 100850, China |
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| Abstract: | Objective To study the effect of O325H on type 2 diabetes.Methods The effects of O325H were investigated in normal KM mice and two kinds of type 2 diabetic mice by intragastric gavage.The possible mechanisms of O325H were investigated by using RT-PCR.Results O325H couldn′t decrease blood glucose in normal mice.However,it could reduce blood lipid level and improve glucose metabolism in type 2 diabetic mice.O325H also increased the expressions of LPL,aP2 and GluT4 mRNA in several tissues.Conclusions O325H is a novel PPARα/γ agonist,which have a great effect to reduce blood lipid and glucose.These results show that O325H has great potential as a prevention and therapy for type 2 diabetes.. |
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| Keywords: | O325H |
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