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术中输血对喉癌患者细胞免疫功能的影响
引用本文:王杰,戴春富,刘思良,王桑,董华雯,谢匡成.术中输血对喉癌患者细胞免疫功能的影响[J].临床耳鼻咽喉头颈外科杂志,2001,15(3):103-105.
作者姓名:王杰  戴春富  刘思良  王桑  董华雯  谢匡成
作者单位:1. 上海市第一人民医院耳鼻咽喉科
2. 复旦大学附属眼耳鼻喉医院耳鼻咽喉科
3. 上海市第一人民医院中心实验室
摘    要:目的 :探讨术中输血对喉癌患者细胞免疫功能的影响。方法 :利用 EPICS- XL 型流式细胞仪对 36例喉癌手术患者于术前及术后 2周进行 T细胞亚群、NK细胞和 CD2 8测定 ,并与正常人及术中输异体血和非输血者进行比较。结果 :136例喉癌患者术前 CD3、CD4、NK细胞、CD2 8下降 ,与对照组比较 ,其差异均有显著性意义 (P<0 .0 1和 0 .0 5 )。 2输异体血组输血后 CD3、CD4、NK细胞、CD2 8下降 ,与治疗前喉癌组比较 ,其差异亦有显著性意义 (均 P <0 .0 5 )。 3非输血组术后 CD3、CD4、CD8、NK细胞、CD2 8与治疗前喉癌组比较 ,其差异均无显著性意义(均 P >0 .0 5 )。结论 :喉癌患者的细胞免疫功能普遍低下 ,术中输异体血会使患者的免疫功能进一步降低 ,使喉癌易于扩散与转移 ,应引起高度重视。

关 键 词:喉肿瘤  T细胞亚群  输血  自然杀伤细胞
文章编号:1001-1781(2001)03-0103-03
修稿时间:2000年8月15日

Effects of blood transfusion on cellular immuno-function in patients with laryngeal carcinoma
WANG Jie,DAI Chunfu,LIU Siliang,WANG Sang,DONG Huawen,XIE Kuangcheng.Effects of blood transfusion on cellular immuno-function in patients with laryngeal carcinoma[J].Journal of Clinical Otorhinolaryngology,2001,15(3):103-105.
Authors:WANG Jie  DAI Chunfu  LIU Siliang  WANG Sang  DONG Huawen  XIE Kuangcheng
Institution:Department of Otolaryngology, First People's Hospital, Shanghai 200080.
Abstract:OBJECTIVE: To explore the influence of blood transfusion on cellular immunofunction in patient with laryngeal carcinoma. METHOD: EPICS-XL flow cytometry was used to measure T cell subgroup, NK cell and CD28 in 36 patients with laryngeal carcinoma pre-operation and 2 weeks post-operation. Patients were divided into allotransfusion group and non-transfusion group. Comparison was conducted between the 2 groups. RESULT: 1. Comparison with normal population, decreasing of CD3, CD4, NK cell and CD28 in the 36 patients pre-operation was statistically significant (P < 0.01). 2. Decreasing of CD3, CD4, NK cell and CD28 was statistically significant post-operation (P < 0.05). 3. In the non-transfusion group change of CD3, CD4, CD8, NK cell and CD28 post-operation was statistically insignificant (P > 0.05). CONCLUSION: While cellular immunofunction is generally low in patients with laryngeal carcinoma, allotransfusion will reduce further. It makes contribution to spreading and metastasis of carcinoma easier.
Keywords:Laryngeal neoplasms  T  Lymphocyte subsets  Blood transfusion  Natural killer cells
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