注射用头孢孟多酯钠与注射用奥美拉唑钠序贯静滴的稳定性研究

目的：研究注射用头孢孟多酯钠与注射用奥美拉唑钠序贯静滴的配伍稳定性。方法：参考临床常用质量浓度，配制头孢孟多酯钠与5%葡萄糖注射液配伍溶液，再取该配伍溶液分别与不同体积的奥美拉唑钠溶液配伍。于0，0.5，1，2，3，4，5，6 h观察各配伍液的外观性状变化，测定pH值和不溶性微粒数，并采用HPLC法测定各配伍液头孢孟多酯钠的相对百分含量。结果：头孢孟多酯钠与5%葡萄糖注射液的配伍液在6 h 内外观无明显变化，与不同体积奥美拉唑钠配伍的配伍液随时间延长出现不同颜色的浑浊，在6 h内各配伍液中不溶性微粒数均符合规定，头孢孟多酯钠的相对百分含量略有下降。结论：在临床上，若注射用头孢孟多酯钠与注射用奥美拉唑钠静滴联用时，最好在两者之间先用0.9%氯化钠注射液清洗输液管道，完毕后再输注另一种药物，或者不将两者连续使用。

Study on the stability of cefamandole nafate for injection and omeprazole sodium for injection with sequential intravenous dripping

OBJECTIVE To investigate the compatible stability of cefamandole nafate for injection and omeprazole sodium for injection in sequential intravenous drip.METHODS According to the clinical common mass concentration,the compatible solution of cefamandole sodium and 5%glucose injection was prepared.The appearance,pH value and insoluble particle number of each compatibility liquid were observed at 0,0.5,1,2,3,4,5,6 h,and the relative percentage of cefamandole sodium was determined by HPLC.RESULTS Under the above conditions,no significant changes of appearance and pH value of the mixed solution of 5%glucose solution had been observed within 6 hours;The compatible solutions with different volumes of omeprazole sodium showed different color turbidity with time.The number of insoluble particles in each compatible solution complied with the requirements within 6 h.the relative percentage content of cefamandole nafate slightly decreased.CONCLUSION In clinical practice,if cefamandole pivoxil sodium for injection is used in combination with omeprazole sodium for injection,it is recommended to clean the infusion pathway with 0.9%sodium chloride injection before the infusion of cefamandole pivoxil sodium,or avoid using both continuously.