SerpinB2 mediated regulation of macrophage function during enteric infection |
| |
Authors: | Terez Shea-Donohue Aiping Zhao Toni M Antalis |
| |
Institution: | 1.Department of Radiation Oncology; University of Maryland School of Medicine; Baltimore, MD USA;2.Department of Medicine; University of Maryland School of Medicine; Baltimore, MD USA;3.Department of Physiology; University of Maryland School of Medicine; Baltimore, MD USA;4.Center for Vascular and Inflammatory Diseases; University of Maryland School of Medicine; Baltimore, MD USA |
| |
Abstract: | Host defense is an orchestrated response involving changes in the expression of receptors and release of mediators from both immune and structural cells. There is a growing recognition of the important role of proteolytic pathways for the protective immune response to enteric pathogens. Enteric nematode infection induces a type 2 immune response with polarization of macrophages toward the alternatively activated phenotype (M2). The Th2 cytokines, IL-4, and IL-13, induce a STAT6-dependent upregulation of the expression of the protease inhibitor, serpinB2, which protects macrophages from apoptosis. M2 are critical to worm clearance and a novel role for serpinB2 is its regulation of the chemokine, CCL2, which is necessary for monocyte and/or macrophage influx into small intestine during infection. There is a growing list of factors including immune (LPS, Th2 cytokines) as well as hormonal (gastrin, 5-HT) that are linked to increased expression of serpinB2. Thus, serpinB2 represents an immune regulated factor that has multiple roles in the intestinal mucosa. |
| |
Keywords: | enteric nematode infection Th2 cytokines macrophage serpinB2 plasminogen activation system |
|
|