Gold Nanoparticles for Nucleic Acid Delivery |
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| Authors: | Ya Ding Ziwen Jiang Krishnendu Saha Chang Soo Kim Sung Tae Kim Ryan F Landis Vincent M Rotello |
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| Affiliation: | 1.Department of Chemistry, University of Massachusetts, Amherst, Massachusetts, USA;2.Department of Pharmaceutical Analysis, Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Ministry of Education, Nanjing, Jiangsu, China |
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| Abstract: | Gold nanoparticles provide an attractive and applicable scaffold for delivery of nucleic acids. In this review, we focus on the use of covalent and noncovalent gold nanoparticle conjugates for applications in gene delivery and RNA-interference technologies. We also discuss challenges in nucleic acid delivery, including endosomal entrapment/escape and active delivery/presentation of nucleic acids in the cell. |
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