| 注射用复方荭草冻干粉针剂对兔离体心脏缺血再灌注损伤的保护作用 |
| |
| 引用本文： | 陶玲,沈祥春,王永林,方泰惠. 注射用复方荭草冻干粉针剂对兔离体心脏缺血再灌注损伤的保护作用[J]. 时珍国医国药, 2006, 17(9): 1650-1652 |
| |
| 作者姓名： | 陶玲 沈祥春 王永林 方泰惠 |
| |
| 作者单位： | 1. 贵阳医学院,贵州,贵阳,550004
2. 南京中医药大学,江苏,南京,210029 |
| |
| 基金项目： | 贵州省中药现代化基金资助项目（No.200403） |
| |
| 摘 要： | 目的观察注射用复方荭草冻干粉针剂(FFHC)对离体家兔心脏缺血再灌注损伤的作用。方法采用离体兔心脏Langendorff灌流,使心脏停灌45m in后复灌,模拟缺血再灌注损伤。以冠脉灌注量、灌注液LDH与CK、以及病理组织学检查为检测指标。结果FFHC高、中剂量组对心脏缺血再灌注损伤具有明显的保护作用,能提高缺血再灌注心脏的冠脉灌注量,抑制缺血再灌注损伤心肌CK和LDH外漏,拮抗缺血再灌注所造成的心肌的组织学损伤。结论FFHC对心肌缺血再灌注损伤具有一定的保护作用。
|
| 关 键 词： | 注射用复方荭草冻干粉针剂 家兔 缺血再灌注 |
| 文章编号： | 1008-0805（2006）09-1650-03 |
| 收稿时间： | 2005-11-01 |
| 修稿时间： | 2006-04-22 |
Protective Effects of FuFangHongCao Freeze - dried Powder Injection on Rabbit Heart Ischemia-Reperfusion Injury in vitro |
| |
| TAO Ling,SHEN Xiang-chun,WANG Yong-lin,FANG Tai-hui. Protective Effects of FuFangHongCao Freeze - dried Powder Injection on Rabbit Heart Ischemia-Reperfusion Injury in vitro[J]. Lishizhen Medicine and Materia Medica Research, 2006, 17(9): 1650-1652 |
| |
| Authors: | TAO Ling SHEN Xiang-chun WANG Yong-lin FANG Tai-hui |
| |
| Affiliation: | 1. Department of Pharmaceutic, Guiyang Medical College, Guiyang, 550004, China ; 2. Department of Pharmacology, Nanfing University of Traditional Chinese Medicine, Nanjing 210029, China |
| |
| Abstract: | Objective To investigate the effects of FuFangHongCao Freeze-dried Powder Injection(FFHC) on rabbit heart ischemia-reperfusion injury in vitro.MethodsTo simulate the ischemia-reperfusion model by blocking perfusion for 45 min,and then reperfusion on rabbit heart with Langendorff perfusion installation in vitro.The flux liquid of coronary artery,LDH and CK activities of perfusion liquid,and pathological histology were assayed.ResultsGroups of high and medium dose of FFHC significantly enhanced the flux liquid of coronary artery of ischemia,inhibited the CK and LDH activities of perfusion liquid,and improved the pathological histology of ischemia-reperfusion.ConclusionFFHC can protect the heart injury induced by ischemia-reperfusion. |
| |
| Keywords: | FuFangHongCao freeze-dried Powder Injection Rabbit Cardiac ischemia-reperfusion |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
