| 慢性缺氧对肺外动脉胶原堆积及胶原基因表达的影响 |
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| 引用本文： | 吴康健 严仪昭. 慢性缺氧对肺外动脉胶原堆积及胶原基因表达的影响[J]. 中华结核和呼吸杂志, 1994, 17(3): 152-155,T017 |
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| 作者姓名： | 吴康健 严仪昭 |
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| 作者单位： | 北京中国医学科学院基础研究所，中国预防医学科学院劳动卫生研究所，中国医学科学院血液研究所 |
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| 摘 要： | 模拟海拔５０００米连续低压缺氧７天复制大鼠肺动脉高压模型，观察结构重建的肺外动脉胶原含量及其基因表达的变化。结构表明：缺氧７天末，大鼠肺动脉压、右心室／左心室＋室间隔重量比值及肺外动脉湿干重量和羟脯氨酸含量均明显升高；经Ｎｏｒｔｈｅｒｎ杂交和斑点杂交分析无交叉和非特异性杂交的编码人Ｐｒｏａ１（Ｉ），Ｐｒｏａ１（Ⅲ）肽链的ｃＤＮＡ探针，进行ＤＮＡ－ＲＮＡ的斑点杂交显示，缺氧组织的Ｐｒｏａ１（Ｉ），ｐ
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| 关 键 词： | 胶原 成纤维细胞 肺性高血压 |
Alternations of collagen content and collagen gene ex-pression in rat vascular structural relnodeling of pul-monary artery induced by hypoxia |
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| Wu Kangjian,YanYizhao,Liu Bingci,et al Institute of Basic Medical Sciences,Peking Union Medical college,Chinese A-cademy of Medical Sciences,Beijing. Alternations of collagen content and collagen gene ex-pression in rat vascular structural relnodeling of pul-monary artery induced by hypoxia[J]. Chinese journal of tuberculosis and respiratory diseases, 1994, 17(3): 152-155,T017 |
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| Authors: | Wu Kangjian YanYizhao Liu Bingci et al Institute of Basic Medical Sciences Peking Union Medical college Chinese A-cademy of Medical Sciences Beijing |
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| Affiliation: | Wu Kangjian,YanYizhao,Liu Bingci,et al Institute of Basic Medical Sciences,Peking Union Medical college,Chinese A-cademy of Medical Sciences,Beijing 100005 |
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| Abstract: | |
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| Keywords: | Hypoxic Pulmonary hypertensionCollagen Fibroblast |
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