| 甘草次酸钠的抗炎作用机理 |
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| 引用本文： | 吴勇杰 常珍梅. 甘草次酸钠的抗炎作用机理[J]. 中国药理学通报, 1991, 7(1): 46-49 |
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| 作者姓名： | 吴勇杰 常珍梅 |
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| 作者单位： | 兰州医学院药理学教研室 730000(吴勇杰，李新芳)，兰州医学院药学系 实习生730000(何琳，刘莉)，兰州市卫生学校病理学教研室 730000(常珍梅) |
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| 摘 要： | 甘草次酸钠(SGA)对多种急性炎症有抑制作用,其抗炎作用不依赖于垂体—肾上腺皮质系统,而和抑制炎症组织中PGE_2生成、拮抗炎症介质组胺、5羟色胺等的作用有关。SGA还抑制蛋白致炎小鼠炎足中PG内过氧化物降解产物丙二醛的生成,此作用可被外源性花生四烯酸拮抗。
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| 关 键 词： | 甘草次酸钠 前列腺素E_2 丙二醛 抗炎 |
ANTI-INFLAMMATORY MECHANISM OF SODIUM GLYCYRRHETINATE |
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| Wu Yongjie,Li Xinfang,He Lin. ANTI-INFLAMMATORY MECHANISM OF SODIUM GLYCYRRHETINATE[J]. Chinese Pharmacological Bulletin, 1991, 7(1): 46-49 |
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| Authors: | Wu Yongjie Li Xinfang He Lin |
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| Abstract: | Glycyrrhetic acid is a hydrolytic product of .glycyrrhizin which comes from Glycyrrhiza uralensis Fisch. This study showed that its sodium salt, sodium glycyrrhetinate ( SGA, 28mg/kg ip ) inhibited egg white or yeast-induced edema of rat hind paws; Meanwhile, SGA decreased prostaglandin E2 in inflammatory fluid. Malonyldialdehyde in mouse swelling paws stimulated by egg white was decreased by SGA and increased by arachidonic acid. The inhibitory action of SGA on production of malonyldialdehyde c.ould be entirely abolished by arachidonic acid,suggesting that phospholipase A2 bo inhibited by SGA. Also, SGA antagonized the contracting effect of inflammatory mediators such as histamine ( IC50 = 12 ,7mg/ L), 5 -hydroxytrypataminG (IC50=16.1 mg/L ) and SRS-A ( IC5O = 17.0mg/L)on isolated guinea-pig ileum. Because SGA inhibited cro-ton oil-induced ear-swelling of adrenalectomized mice, its anti-inflammatory action has no relationship with hypophysial-adrenocortial axis. |
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| Keywords: | Sodium glycyrrhetinate Prostaglandin E2 Malonyldialdehyde Anti-inflammation |
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