| 吗丙嗪的药物动力学研究 |
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| 引用本文： | 胡艳平,张覃沐.吗丙嗪的药物动力学研究[J].中国药理学通报,1991,7(5):392-394. |
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| 作者姓名： | 胡艳平 张覃沐 |
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| 作者单位： | 河南省医科所药理室 郑州450052
(胡艳平)，河南省医科所药理室 郑州450052(张覃沐) |
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| 摘 要： | 按75mg/kg给家兔灌胃吗丙嗪,体内药物动力学呈开放性二室模型。将每组数据按Marquardt法迭代拟合,多项指标帮助选择最佳模型。模型分析得其参数为:T_(1/2)α=0.19h,T_(1/2)β=4.96h,K_(21)=2.94h~(-1),K_(10)=0.69h~(-1),K_(12)=3.75h~(-1),AUC=98.91h·mg/L,CLs=0.76L·kg~(-1)·h~(-1),V/f(c)=1.09L·kg~(-1),Vss=1.51L·kg~(-1),分析结果表明:吗丙嗪主要分布于血流丰富的大循环和组织,肝脏为主要消除器官,肾脏及胃肠道均有排泄。
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| 关 键 词： | 吗丙嗪 药物动力学 房室模型 Marquardt法 |
STUDY ON PHARMACOKINETICS OF PROBIMANE FOR ORAL ADMINISTRATION IN RABBIT |
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| Hu Yanping,Zhang Tanmu.STUDY ON PHARMACOKINETICS OF PROBIMANE FOR ORAL ADMINISTRATION IN RABBIT[J].Chinese Pharmacological Bulletin,1991,7(5):392-394. |
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| Authors: | Hu Yanping Zhang Tanmu |
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| Abstract: | Pharmaco kinetics of probimane in rabbits was studied by using high-performance liguid chromatography. After the oral adiminis-tration of probimane 75mg/kg to rabbits,the phatmacokinetic characteristics are found to fit a two compartment open model. The pharmacokinetic parameters are: tl/2α = 0.1933h, tl/2β = 4.9568h, K21 =2.9410h-1, K10=0.6492h-1 K12=3.75l2h-1 AUC = 98.9l01h · mg/L, Cls=0.7583L· kg-1 · h-1, V/f(c) = 1.0924L · kg-1, VSS=1.5114L. kg-1. |
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| Keywords: | Probimane Pharmacokinetics Compartment model Marguardt method |
| 本文献已被 CNKI 维普 等数据库收录！ |
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