| 维拉帕米和糖基化对细胞内胆固醇含量的影响 |
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| 引用本文： | 刘乃丰,楼定安.维拉帕米和糖基化对细胞内胆固醇含量的影响[J].中国药理学通报,1991,7(1):63-66. |
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| 作者姓名： | 刘乃丰 楼定安 |
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| 作者单位： | 南京铁道医学院附属医院心内科 210009
(刘迺丰)，浙江医科大学病理解剖教研室 杭州310031(楼定安) |
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| 摘 要： | 用国产酶联试剂检测培养细胞内微量胆固醇的方法简便、快速、价廉、灵敏度高,以此观察了不同培养条件及糖基化低密度脂蛋白和维拉帕米对细胞内胆固醇含量的影响。
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| 关 键 词： | 钙拮抗剂 维拉帕米 糖基化 低密度脂蛋白 胆固醇 |
EFFECT ON INTRACELLUIAR LIPID METABOLISM BY VERAPAMIL AND GLUCOSYLATED LDL |
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| Liu Naifeng,Lou Dingan.EFFECT ON INTRACELLUIAR LIPID METABOLISM BY VERAPAMIL AND GLUCOSYLATED LDL[J].Chinese Pharmacological Bulletin,1991,7(1):63-66. |
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| Authors: | Liu Naifeng Lou Dingan |
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| Abstract: | This study was designed to investigate the effects of calcium antagonists and glucosylated LDL on intracellular lipid metabolism . The human serum LDL was isolated by density gradient ultracentri-fugation and glucosylated by incubation with glucose. The content of intracellular cholsterol was determined by enzymatic method which is simple, convenient and satisfactory. It was found that the contents of cholesterol in cultured human fibroblasts incubated with verapamil and(or)glucosylated LDL were higher than those incubat- ed with control LDL or without verapamil. The results suggested that calcium antagonists and glucosylation of LDL might affect in-tracellular lipid metabolism and play a role in atherosclerosis. |
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| Keywords: | Calcium antagonists Verapamil Glucosylation Low density lipoprotein Cholesterol |
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