| 吗啡加快体外培养乳鼠心肌细胞的搏动频率 |
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| 引用本文： | 陈建光,马肃.吗啡加快体外培养乳鼠心肌细胞的搏动频率[J].中国药理学通报,1991,7(4):287-289. |
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| 作者姓名： | 陈建光 马肃 |
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| 作者单位： | 吉林医学院药理教研室 吉林132001
(陈建光，马肃)，吉林医学院药理教研室 吉林132001(崔新影) |
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| 摘 要： | 10~(-8)mol/L、5.5×10~(-8)mol/L、10~(-7)mol/L的硫酸吗啡使体外培养的乳鼠心肌细胞搏动频率分别增加9%、32%和81%。具有量效关系。纳络酮(10~(-5)mol/L)能完全取消吗啡的此种作用。而普萘洛尔(10~(-5)mol/L)却不影响吗啡的作用。这一结果提示吗啡可直接加快心肌细胞的搏动频率,可能是通过激动吗啡受体而作用的
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| 关 键 词： | 吗啡 纳络酮 培养心肌细胞 搏动频率 |
MORPHINE INCREASES THE BEATING RATE IN CULTURED RAT HEART CELLS |
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| Chen Jianguang,Ma Su,Cui Xinying.MORPHINE INCREASES THE BEATING RATE IN CULTURED RAT HEART CELLS[J].Chinese Pharmacological Bulletin,1991,7(4):287-289. |
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| Authors: | Chen Jianguang Ma Su Cui Xinying |
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| Abstract: | At the concentrations of 10-8mol/L, 5.5×l0-8mol/L, 10-7mol/L morphine produced a dose-dependent increase of beating rate in cultured rat heart cells with 9%,32%and 81% respectively. The increase was antagonized by opiate antagonist naloxone ( 10-5mol/L ) , but not affected by propranolol ( 10-5mol/L ) which could cancel the positive chronotropy of isoprenaline ( 10-9mol/L ) on the beating cells. The results support the concept that morphine may be a direct effect on myocadium, perhaps through opiate receptors. |
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| Keywords: | Morphine Naloxone Cultured heart cells Beating rate |
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