| 鹿茸神经节甙酯对小鼠学习记忆功能的影响 |
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| 引用本文： | 徐惠波,张洁.鹿茸神经节甙酯对小鼠学习记忆功能的影响[J].中国药理学通报,1991,7(5):385-388. |
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| 作者姓名： | 徐惠波 张洁 |
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| 作者单位： | 吉林省中医中药研究院中药所药理室 长春130021
(徐惠波，王本祥)，吉林省医药工业研究所药理室 130062
(张洁)，长春市卫校 八九届毕业实习生(孙冶) |
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| 摘 要： | 多次皮下注射鹿茸神经节甙酯0.5g/kg对小鼠记忆获得、记忆再现、记忆巩固三个不同记忆阶段均有明显的促进作用;对~3H]Leu-cine和~3H]Uridine掺入小鼠脑组织蛋白和RNA有明显增加作用。此结果提示:鹿茸神经节甙酯促进学习记忆功能与小鼠脑内的蛋白质合成增加有密切关系。
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| 关 键 词： | 神经节甙酯 学习记忆功能 蛋白质 |
THE EFFECT OF GANGLIOSIDES FROM CERVUS NIPPON TEMMINCK ON LEARNING AND MEMORY FUNCTION OF MICE |
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| Xu Huibo,Wang Benxiang,Zhang Jie.THE EFFECT OF GANGLIOSIDES FROM CERVUS NIPPON TEMMINCK ON LEARNING AND MEMORY FUNCTION OF MICE[J].Chinese Pharmacological Bulletin,1991,7(5):385-388. |
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| Authors: | Xu Huibo Wang Benxiang Zhang Jie |
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| Abstract: | Repeated administrations of gangliosides extracted from Cervus nippon Temminek exerted remarkable facilitation action on the acquisition, retrieval and consolidation of memory in mice. It was able to increase the incorporations of 8H] Leucine into protein and 3H] Uridine into RNA in mouse brain tissue. It was suggested that the above-mentioned actions of gangliosides may be due to the promoting action for the synthesis of protein in brain tissue. |
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| Keywords: | Gangliosides Learning and memory function Protein |
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