| 18β-甘草次酸钠抗缺氧机理的初步探讨 |
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| 引用本文： | 葛明珠 李新芳. 18β-甘草次酸钠抗缺氧机理的初步探讨[J]. 中国药理学通报, 1991, 7(4): 297-299 |
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| 作者姓名： | 葛明珠 李新芳 |
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| 作者单位： | 兰州医学院病生教研室 730000(葛明珠，张志琳，潘兴斌)，兰州医学院药理教研室 730000(李新芳)，兰州医学院药理教研室 730000(吴勇杰) |
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| 摘 要： | 18β-甘草次酸钠ip 14mg/kg、21mg/kg使乏氧性缺氧小鼠的存活时间延长,小鼠的整体耗氧率降低,小鼠血液pH值提高,酸中毒减轻,也能使混合血的氧分压降低,但对小鼠血中甲状腺素含量无明显影响。
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| 关 键 词： | 18β-甘草次酸钠 缺氧 抗缺氧 代谢性酸中毒 甲状腺素 |
PRELIMINARY REPORTS OF THE STUDIES ON ANTIHYPOXIA MECHANISM OF 18β-SGA |
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| Ge Mingzhu,Zhang Zhilin,Pan Xingbin. PRELIMINARY REPORTS OF THE STUDIES ON ANTIHYPOXIA MECHANISM OF 18β-SGA[J]. Chinese Pharmacological Bulletin, 1991, 7(4): 297-299 |
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| Authors: | Ge Mingzhu Zhang Zhilin Pan Xingbin |
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| Abstract: | The studies on the antihypoxia mechanism of 18β-SGA were reported. The survival time of hypoxia mice were longer than those of the control after intraperitoneal injections of 14mg/kg or 21mg/kg of 18β-SGA ( Sodium 18β-glycyrrenetic acid). Changes of various physiological indications after administration of the drug were as follows: blood pH was risen; acidosis was relieved; and the partial pressure of oxygen in the mixed blood was decreaed. The blood thyroxine level remain unchanged. It suggests the utilization of oxygen by the tissues was strengthened. |
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| Keywords: | 18β-SGA Hypoxia Antihypoxia Disbalance of acid-base Thyroxine |
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