| 三七皂甙D_1对家兔急性脑缺血的保护作用 |
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| 引用本文： | 李麟仙,王子灿.三七皂甙D_1对家兔急性脑缺血的保护作用[J].中国药理学通报,1991,7(5):350-353. |
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| 作者姓名： | 李麟仙 王子灿 |
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| 作者单位： | 昆明医学院病理生理教研室 云南650031
(李麟仙，王子灿，李盈盈，李树清)，昆明医学院病理植化室 云南650031(魏均娴) |
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| 基金项目： | 云南省科委应用基础基金资助课题 |
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| 摘 要： | 分别采用低压低灌,4根动脉闭塞方法造成家兔急性不完全性脑缺血,急性前脑缺血再灌流损伤模型,用大脑皮质EEG,皮质组织Na~+、K~+,水含量,脑静脉血中LDH、CPK活性,低灌时的最大失血量等为指标,观测三七皂甙D_1对家兔急性脑缺血的保护作用,结果给药组的上述各项参数均得到明显改善,表明三七皂甙D_1对家兔急性脑缺血有一定保护作用。
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| 关 键 词： | 三七皂甙D_1 急性脑缺血 脑电图 乳酸脱氢酸 磷酸肌 酸激酸 |
THE PROTECTIVE EFFECT OF SANCHINOSIDE D_1 ON ACUTE CEREBRAL ISCHEMIA IN RABBITS |
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| Li Linxian,Wang Zican,Li Yingying et al.THE PROTECTIVE EFFECT OF SANCHINOSIDE D_1 ON ACUTE CEREBRAL ISCHEMIA IN RABBITS[J].Chinese Pharmacological Bulletin,1991,7(5):350-353. |
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| Authors: | Li Linxian Wang Zican Li Yingying |
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| Abstract: | Acute in-complete cerebral ischemia were induced in 39 rabbits by hypotension coupled with hypoperfusion for 60 min, and acute forebrain ischemia were induced in other 15 rabbits by 4A-Occlus-ion for 30 min followed by reperfusion 120 min. At the end of experiment, EEG, the tissue contents of sodium,potassium and water in the cerebral cortex, the activities of LDH and CPK in the cerebral venous blood and the maximal bleeding volume were estimated. Sanchinoside D1 ( 50mg/kg, i.v.) could ameliorate significantly all the changes of relevant parameters mentioned above in model animals. It was suggested that Sanchinoside D1 had some protective effect on acute cerebral ischemia in rabbits |
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| Keywords: | Sanchinoside D1 Cerebral ischemia LDH CPK EEG |
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