| Clinical Study on Effect of Garlicin in Stabilizing the Carotid Artery Atherosclerotic Plaque in Patients with Primary Hypertension and Coronary Artery Disease |
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| 引用本文： | 程文立,柯元南,史载祥,王瑛,陈莉,鞠镐,范书英. Clinical Study on Effect of Garlicin in Stabilizing the Carotid Artery Atherosclerotic Plaque in Patients with Primary Hypertension and Coronary Artery Disease[J]. 中国结合医学杂志, 2006, 12(3): 166-170. DOI: 10.1007/BF02836515 |
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| 作者姓名： | 程文立 柯元南 史载祥 王瑛 陈莉 鞠镐 范书英 |
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| 作者单位： | Department of National Integrative Medicine Center for Cardiovascular Diseases China-Japan Friendship Hospital，Beijing (100029)，Department of National Integrative Medicine Center for Cardiovascular Diseases，China-Japan Friendship Hospital，Beijing (100029)，Department of National Integrative Medicine Center for Cardiovascular Diseases，China-Japan Friendship Hospital，Beijing (100029)，Department of National Integrative Medicine Center for Cardiovascular Diseases，China-Japan Friendship Hospital，Beijing (100029)，Department of National Integrative Medicine Center for Cardiovascular Diseases，China-Japan Friendship Hospital，Beijing (100029)，Department of National Integrative Medicine Center for Cardiovascular Diseases，China-Japan Friendship Hospital，Beijing (100029)，Department of National Integrative Medicine Center for Cardiovascular Diseases，China-Japan Friendship Hospital，Beijing (100029) |
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| 摘 要： | Objective:To investigate the effect of garlicin in treating carotid artery atherosclerotic plaque (GAAP) in patients with primary hypertension and coronary heart disease (PHT-CHD).Methods:Seventynine patients with PHT-CHD were randomly divided into the treated group (39 patients) treated with garlicin and fosinopril and the control group (40 patients) treated with fosinopril alone. The change of CAAP was evaluated by high frequency ultrasonic examination every six months, and the changes of intercellular adhesion molecule-1 (ICAM-1) and high sensitive C-reactive protein (hs-CRP) were measured by ELISA, with the observation proceeding for 52 weeks totally. Results:By the end of the experiment, the number of complex plaques, Crouse integrals, intima-media thickness, serum ICAM-1 and hs-CRP were significantly lower in the treated group than those in the control group with significant difference (P<0.05). Conclusion:Garlicin could stabilize CMP to a certain extent and shows a definite vascular protective effect in patients with PHT-CHD.
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| 收稿时间： | 2006-06-28 |
Clinical Study on Effect of Garlicin in Stabilizing the Carotid Artery Atherosclerotic Plaque in Patients with Primary Hypertension and Coronary Artery Disease |
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| CHENG Wen-li,KE Yuan-nan,SHI Zai-xiang,WANG Ying,CHEN Li,JU Gao,FAN Shu-ying. Clinical Study on Effect of Garlicin in Stabilizing the Carotid Artery Atherosclerotic Plaque in Patients with Primary Hypertension and Coronary Artery Disease[J]. Chinese journal of integrative medicine, 2006, 12(3): 166-170. DOI: 10.1007/BF02836515 |
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| Authors: | CHENG Wen-li KE Yuan-nan SHI Zai-xiang WANG Ying CHEN Li JU Gao FAN Shu-ying |
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| Abstract: | Objective:To investigate the effect of garlicin in treating carotid artery atherosclerotic plaque (GAAP) in patients with primary hypertension and coronary heart disease (PHT-CHD).Methods:Seventynine patients with PHT-CHD were randomly divided into the treated group (39 patients) treated with garlicin and fosinopril and the control group (40 patients) treated with fosinopril alone. The change of CAAP was evaluated by high frequency ultrasonic examination every six months, and the changes of intercellular adhesion molecule-1 (ICAM-1) and high sensitive C-reactive protein (hs-CRP) were measured by ELISA, with the observation proceeding for 52 weeks totally. Results:By the end of the experiment, the number of complex plaques, Crouse integrals, intima-media thickness, serum ICAM-1 and hs-CRP were significantly lower in the treated group than those in the control group with significant difference (P<0.05). Conclusion:Garlicin could stabilize CMP to a certain extent and shows a definite vascular protective effect in patients with PHT-CHD. |
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| Keywords: | garlicin primary hypertension coronary heart disease atherosclerotic plaque intercellular adhesion molecule-1 high sensitive C-reactive protein |
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