Experience of a combination chemotherapy consisting of 5-FU, MMC, and FT-207--side effects against kidney

We are using 5-FU, MMC, and FT-207 in combination for the treatment of the patients with gastric cancer for a long term, and the renal dysfunction was found in two cases. The 1st case was a 69 years old male, suffering from gastric cancer which was unresectable. He was treated with the anticancer drugs for 2.5 years after exploratory laparotomy and no development of gastric cancer was detected endoscopically. But renal function of the patient was damaged. The 2nd case was a 58 years old male, also suffering from gastric cancer. The chemotherapy lasting for 1.5 years after gastrectomy resulted also in renal dysfunction.