马来酸桂哌齐特治疗急性脑梗死的临床分析

目的探讨马来酸桂哌齐特注射液(商品名克林澳)治疗急性脑梗死(ACI)的临床疗效。方法将64例急性脑梗死患者随机分为两组,两组患者除给予常规治疗外,治疗组32例给予克林澳320mg为主治疗,加入生理盐水250ml静脉滴注,每日一次；对照组32例(即治疗方法之一)给予川芎嗪0．2g 胞二磷胆碱1．0g为主治疗,加入生理盐水250ml静脉滴注,每日一次。两组患者均治疗两周,观察治疗前后临床疗效和纤维蛋白原、凝血酶原时间的生化指标进行对比分析。结果治疗组显效率68．7％,对照组显效率34．4％,两组基本痊愈和显效比较有明显差异(P<0．05),且治疗组血浆纤维蛋白原明显降低(P<0．05)。结论马来酸桂哌齐特注射液治疗急性脑梗塞疗效肯定,能明显改善神经功能的损伤。减少了并发症和后遗症的发生,是一种安全有效的药物。

Clinical obervation on the effect of cinepazide maleate on patients with acute cerebral infarction

To study the clinical effect of Cinepazide maleate on patients with acute cerebral infarction (ACI). Methods 64 cases of ACI were randomly divided into observation group consisted of 32 cases treated with cinepazide maleate and control group consisted of 32 cases treated with ligustrazine and citicoline. Besides given routine treatment of patients in both groups, cinepazide maleate 320mg 0.9%NS250ml was given to patients in observation group once per day by intravenous drop and Ligustrazine0.2g Citicolinel. Og 0.9%NS250ml by intravenous drop once per day for a course of two weeks. The effect and variation of chemical criteria of fibrinogen and prothrombin before and after treatment were analyzed. Results The effective rate was 72 % in the treatment group,46% in the control group, showing significant difference (P<0.05). And the level of fibrinogen in the treatment group was significant low(P<0.05). Conclusion Cinepazide Maleate was an effective in treating acute cerebral infarction, it is a effective and safe drug as it could obviously improve injury to nerve function, reduce the occurrence of complication and sequels of cerebral embolism.