高血压患者血清磷酯脂肪酸谱与血脂的相关性研究

目的研究高血压患者血清磷酯脂肪酸谱与血脂的相关性。方法采用高效气相色谱法测定高血压患者和健康对照者的血清磷酯脂肪酸谱,酶法测定血脂。结果高血压组的14:0、16:0、18:0和饱和脂肪酸(SFA)较对照组显著升高,16:1、18:1、18:2n-6、20:5n-3、单不饱和脂肪酸(MUFA)、n-6多不饱和脂肪酸(n-6 PUFA)、n-3多不饱和脂肪酸(n-3 PUFA)和多不饱和脂肪酸(PUFA)较对照组显著降低。总胆固醇(TC)与18:0正相关,而与16:1和18:1负相关;甘油三酯(TG)与18:2n-6、20:5n-3、和PUFA负相关;高密度脂蛋白胆固醇(HDL-C)与)18:2n-6、20:4n-6和n-6PUFA正相关;低密度脂蛋白胆固醇(LDL-C)与14:0和16:0正相关,而与n-3PUFA负相关。结论高血压血清磷酯脂肪酸谱中SFA高于健康对照,MUFA和PU-FA低于健康对照。而与血脂的相关分析显示SFA与高血压的血脂升高有关,而MUFA和PUFA对高血压患者的血脂具有保护作用。

The Correlation between Serum Phospholipid Fatty Acids and Blood Lipids in Hypertension

Objective To investigate the relationship between serum phospholipid fatty acids and lipoprotein lipids.Methods study included 28 hypertension patients and 30 health people.Plasma phospholipid fatty acid and lipids were measured in all subjects.Plasma phospholipid fatty acid was analyzed with capillary gas chromatography.Plasma lipids were measured by enzymatic assay.Results The composition of 14:0,16:0,18:0 and total SFA in hypertension group was significantly higher than that in healthy group,while 16:1,18:1,18:2n-6,20:5n-3,MUFA,n-6 PUFA and n-3 PUFA was significantly lower than that in healthy group.Bivariate correlate analysis showed that TC was positively correlated with 18:0,and negatively correlated with 16:1 and 18:1;TG was singificantly negatively correlated with 18:2n-6,20:5n-3 and total PUFA;HDL-C was positively correlated with 18:2n-6,20:4n-6 and n-6PUFA;LDL-C was positively correlated with 14:0 and 16:0,and negatively correlated with n-3PUFA.Conclusions In hypertension group plasma phosholipid total SFA was higher than in normal control gruop,total MUFA and PUFA were lower than those in control group.Present results showed that the dietary SFA intake may contribute to blood ilipid metaboklism system,and MUFA and PUFA intake may have a protective effect.