超声对不同染毒剂量兔肾背向散射积分的研究

目的：探讨背向散射积分（IBS）技术描述不同剂量有机磷中毒兔肾改变的价值。方法：建立兔急性有机磷中毒动物模型，分别于染毒后1h和3h对四个不同剂量实验组及对照组行二维超声和IBS检查、二维超声观察肾回声，测量肾大小，IBS定量分析肾改变：结果：任一剂量组染毒后肾回声均无改变。随着剂量的增大和染毒时间的延长，肾体积、长径与对照组相比差异均有显著性意义（P〈0．05），体积的变化早于长径。染毒1h后，3．75mL／kg组和5．00mL／kg组肾皮质和髓质IBS％与对照组相比差异有显著性意义（P〈0．05）；染毒3h后，2．50mL／kg组、3．75mL／kg组和5．00mL／kg组肾皮质和髓质IBS％与对照组相比差异有显著性意义（P〈0．05）：结论：不同染毒剂量有机磷类化合物中毒兔肾IBS改变与其病理变化相关，超声检查可为诊断有机磷中毒肾损害提供依据

Integrated backscatter of kidney in rabbits with different dosage poisoning

Objective: To explore the value of integrated backscatter(IBS) of kidney with different dosage of organophosphorus in rabbits. Methods: Animal models of organophosphorus poisoning were established. Ultrasonographic examinations were performed on four different dosage experimental groups and control group at 1h and 3 h after rabbits being poisoned.The echo and the size of kidney were evaluated by two-dimensional ultrasound.The changes of parenchyma were quantitatively analyzed by IBS.Results: No significant changes were found in kidney echo of any groups.With the increasing dosage and prolonging time of poisoning,significant changes were found in volume and length of kidneys comparing with that of control group(P<0.05).The change in volume emerged earlier than that in length.There was significant differences in IBS% of both cortex and medulla in group 3 and 4 comparing with that of control group 1 h after poisoning(P<0.05).There was significant difference in IBS% of both cortex and medulla in group 2,3 and 4 comparing with that of control group 3 h after poisoning(P<(0.05).) Conclusion:The IBS% changes of rabbit kidney were related to the renal pathology after different dosage of organophosphorus poisoning.Ultrasonography could provide useful information in the diagnosis of organophosphorus impaired kidney.