Association of PTPN22 C1858T and CTLA-4 A49G polymorphisms with type 1 diabetes in Croatians |
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| Affiliation: | 1. Division of Molecular Medicine, Ruđer Bošković Institute, Zagreb, Croatia;2. Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Zagreb, Croatia;1. Division of Medical Imaging, Health Management Center, Cheng-Hsin General Hospital, Taipei, Taiwan;2. Heart Center, Cheng-Hsin General Hospital, No. 45, Zhenxing Street, Beitou District, Taipei, Taiwan;3. Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan;4. Institute of Microbiology and Immunology, School of Medicine, National Yang-Ming University, Taipei, Taiwan;5. Faculty of Medicine, National Defense Medical Center, Taipei, Taiwan;6. Graduate Institute of Clinical Medicine, National Taiwan University, Taipei, Taiwan;1. Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health and the Welch Center for Prevention, Epidemiology and Clinical Research;2. Department of Medicine, Johns Hopkins University School of Medicine;3. Division of Epidemiology and Community Health, School of Public Health, University of Minnesota;4. Departments of Medicine and Population Health Sciences, University of Wisconsin School of Medicine and Public Health;5. Department of Medicine, Section of Cardiovascular Research, Baylor College of Medicine and Houston Methodist DeBakey Heart and Vascular Center;6. Epidemiological Cardiology Research Center (EPICARE), Department of Epidemiology and Prevention, and Department of Internal Medicine-Cardiology, Wake Forest School of Medicine;7. Cardiovascular Division, Department of Medicine, University of Minnesota Medical School;8. Department of Pathology, Johns Hopkins University School of Medicine;1. Laboratory of Cardiovascular Pharmacology, School of Medical Sciences, University of Campinas, Campinas, SP, Brazil;2. Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, SP, Brazil;3. University of Brasilia (UnB), DF, Brazil;4. Department of Internal Medicine-Cardiology Division, Faculty of Medical Sciences, University of Campinas, SP, Brazil |
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| Abstract: | In this case–control study the association between the PTPN22 1858T and CTLA-4 49G gene variants and T1D in Croatian population was examined. We found that distribution of PTPN22 C1858T and CTLA-4 A49G genotypes between T1D patient (n = 102) and control (n = 193) groups differ significantly (p < 0.0001 and p = 0.012, respectively). Moreover, although the risk alleles of both SNPs are distributed more frequently in patients, the significant difference is observed only for PTPN22 1858T allele (p < 0.0001). This is therefore the first evidence that analyzed gene variants contribute to T1D pathogenesis in Croatian population. |
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