New amphiphilic and pH-sensitive hydrogel for controlled release of a model poorly water-soluble drug |
| |
| Affiliation: | 1. University of Rouen, Mont Saint Aignan, France;2. “Petru Poni” Institute of Macromolecular Chemistry, Iasi, Romania;1. Department of Computer Science, Tianjin University of Technology and Education, Tianjin 300222, China;2. Department of Mechanical Engineering, University of California, Berkeley, CA 94720-1740, USA;3. Department of Mechanical Engineering, Tianjin University of Science and Technology, Tianjin 300222, China;1. Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Life Sciences, University of Vienna, Vienna 1090, Austria;2. Department of Pharmacognosy, University of Vienna, Vienna 1090, Austria;3. Department of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Vienna 1090, Austria;4. Research Platform “Characterisation of Drug Delivery Systems on Skin and Investigations of Involved Mechanisms”, University of Vienna, Vienna 1090, Austria;1. Unit of Medical Physics, IEO, European Institute of Oncology IRCCS, Via Ripamonti 435, I 20132 Milan, Italy;2. Department of Physics, University of Milan, Via Festa del Perdono, 7, 20122 Milan, Italy;3. Division of Radiation Oncology, IEO, European Institute of Oncology IRCCS, Via Ripamonti 435, I 20132 Milan, Italy;4. Department of Oncology and Hemato-oncology, University of Milan, Via Festa del Perdono, 7, 20122 Milan, Italy;5. Scientific Directorate, IEO, European Institute of Oncology IRCCS, Via Ripamonti 435, I 20132 Milan, Italy;1. Chemistry Centre and Chemistry Department, University of Minho, 4710-057 Braga, Portugal;2. Chemistry Department, University of Trás-os-Montes e Alto Douro, 5000-801 Vila Real, Portugal;3. IFSC, University of São Paulo, 13560-970 São Carlos, SP, Brazil;4. CQ-VR, University of Trás-os-Montes e Alto Douro, 5000-801 Vila Real, Portugal;5. IQSC, University of São Paulo, 13566-590 São Carlos, SP, Brazil;1. Conductive and Electroactive Polymers Research Unit, The Petroleum and Petrochemical College, Chulalongkorn University, Bangkok, 10330, Thailand;2. Department of Materials Science and Engineering, Faculty of Engineering and Industrial Technology, Silpakorn University, Nakorn Pathom, 73000, Thailand |
| |
| Abstract: | This paper presents the development of new pH-sensitive, amphiphilic and biocompatible hydrogels based on alginate-g-PCL, cross-linked with calcium ions to form beads, prepared for controlled delivery of poorly water-soluble drug. We have focused our study on the effect of the length of PCL chains (530 and 1250 g mol−1). Swelling profiles obtained clearly indicated that these hydrogels swell slightly (10–14%) in a simulated gastric fluid (pH 1.2), and strongly (700–1300% before disintegration) in a simulated intestinal fluid (pH 6.8). In both media, rates of swelling were lower for beads based on amphiphilic derivatives than for alginate/Ca2+ ones due to the hydrophobic PCL grafts, and decreased when hydrophobic character increased. A model drug, theophylline, was entrapped into these hydrogels and release studies were carried out. The drug was protected in acidic fluid (only 14–20% of release for alginate-g-PCL hydrogel against 35% of release for alginate hydrogel during 350 min). The drug is released completely in neutral fluid due to ion exchanges and disintegration of the hydrogel. PCL leads to decrease in the release kinetics in SIF (2 h for alginate-g-PCL/Ca2+ beads against 1 h for alginate/Ca2+ beads). It was demonstrated that the establishment of clusters inside beads by intramolecular interactions between PCL grafts of 530 g mol−1 in salt media allowed to retain the drug and to slow down its release considerably. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
