Thromboxane as a possible hepatotoxic factor increased by endotoxemia in obstructive jaundice |
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Authors: | Takumi Hanai MD Jiro Yura Kenji Ogino Keiichi Hori Tatsuya Suzuki |
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Institution: | (1) The First Department of Surgery, Nagoya City University Medical School, 1-Kawasumi, Mizuho-cho, Mizuho-ku, 467 Nagoya, Japan |
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Abstract: | In a study using rats, we investigated whether liver damage induced by endotoxemia in obstructive jaundice is associated with
thromboxane (TX) in order to acertain whether its vasoconstrictive and platelet aggregating properties play a role in reducing
liver blood flow. The rats were divided into the following 5 groups; a control group, an endotoxin (Et) group, a bile duct
ligation (BDL) group, a bile duct ligation and endotoxin (BDL+Et) group and an OKY046 (Thromboxane synthetase inhibitor) treated
bile duct ligation+endotoxin (OKY-BDL+Et) group. The blood TXB2 levels in the Et, BDL and BDL+Et groups were higher than those in the control group. The liver TXB2 levels in the Et and BDL+Et groups were also higher than those in the control group. Liver phospholipids and liver blood
flow decreased in the BDL+Et group, whereas in the OKY-BDL+Et group they returned close to the control group levels by decreasing
the TXB2 levels in both the liver and blood to normal. These results suggest that the high level of TX in the blood and liver tissue
may further aggrevate the liver during endotoxemia in obstructive jaundice by inhibiting liver blood flow. |
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Keywords: | endotoxemia obstructive jaundice thromboxane liver phospholipid liver blood flow |
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