我院2008-2012年抗感染药物应用及细菌耐药趋势分析

目的:分析我院抗感染药物近5年的用药现状和耐药菌株耐药率发展趋势,为抗感染药物采购、供应和临床合理应用提供参考。方法:采用我院2008-2012年购药信息,对抗感染药物品种、金额进行排序分析;计算用药频度(DDDs)和绘制细菌耐药趋势图。结果:5年来抗感染药物消耗呈上升趋势,DDDs却逐年下降;细菌耐药率呈缓慢上升趋势,铜绿假单胞菌耐药率呈下降趋势,肺炎克雷伯菌、大肠埃希菌耐药率呈先降后升趋势。结论:抗感染药物临床使用量大,同时近年细菌耐药率呈增长趋势。2008年来由于国家对抗感染药物使用率采取控制措施,使得抗感染药物用量和DDDs下降,促使临床抗感染药物DDDs趋于合理;然而细菌耐药率上升的结果并不随着DDDs降低而降低,揭示细菌耐药率上升是由多种因素共同作用导致,其相关性机制应当进一步深入研究。

Analysis of the Utilization of Anti-infective Drugs and the Trend of Bacterial Drug Resistance in Our Hospital during 2008--2012

OBJECTIVE： To analyze the application and development trend of anti-infective drugs in our hospital in nearly 5 years, and to provide reference for the purchase, supply and rational use of anti-infective drugs based on the trends of drug-resistant strains samples. METHODS： The type and amount of drugs were sorted and analyzed by adopting drug purchase information during 2008 -- 2012. The situation and development trend of anti-infective drugs were analyzed by calculating DDDs and regional bacteria resistant rate. RESULTS： The consumption of anti-infective drugs showed an up trend in recent 5 years, while the DDDs of anti-infective drugs were decreased year by year. The resistance rate of bacteria was increased slowly. The resistant rate of Pseudomonas aeruginosa showed a declining trend, and Klebsiella pneumoniae and Escherichia coli feel first and rose at last. CONCLUSIONS： A large amount of anti-infective drugs have been used while the bacteria resistant rate shows a trend of growth in recent years. The amount and DDDs of anti-infective drugs are decreased by controlling the utilization of anti-infective drugs in 2008 to improve the rationality of anti-infective drugs. However, resistance rate of bacteria doesn＇ t decrease with the decrease of DDDs. The increase of bacterial resistance rate is caused by multiple factors, and the correlation mechanism should be further studied.