| 益心舒胶囊对大鼠心肌缺血再灌注损伤的保护作用 |
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| 引用本文： | 刘家稳,刘新义,李健和,向大雄,易利丹,胡雄彬,叶祖光.益心舒胶囊对大鼠心肌缺血再灌注损伤的保护作用[J].中国中药杂志,2013,38(12):2005-2008. |
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| 作者姓名： | 刘家稳 刘新义 李健和 向大雄 易利丹 胡雄彬 叶祖光 |
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| 作者单位： | 中南大学 湘雅二医院 新制剂开发重点研究室, 湖南 长沙 410013;中南大学 湘雅二医院 新制剂开发重点研究室, 湖南 长沙 410013;中南大学 湘雅二医院 新制剂开发重点研究室, 湖南 长沙 410013;中南大学 湘雅二医院 新制剂开发重点研究室, 湖南 长沙 410013;中南大学 湘雅二医院 新制剂开发重点研究室, 湖南 长沙 410013;中南大学 湘雅二医院 新制剂开发重点研究室, 湖南 长沙 410013;中国中医科学院, 北京 100700 |
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| 摘 要： | 目的: 观察益心舒胶囊对SD大鼠心肌缺血再灌注损伤(MIRI)的保护作用. 方法: 将60只SD大鼠随机分为6组:假手术组、MIRI模型组、心速宁胶囊组、益心舒胶囊低、中、高剂量组(5,10,15 mg·kg-1).采用结扎冠状动脉左前降支30 min后再灌注120 min的方法复制急性MIRI大鼠模型,测定各组MIRI大鼠血清肌酸激酶(CK)、乳酸脱氢酶(LDH)、天门冬氨酸氨基转移酶(AST)和丙二醛(MDA)含量,血液黏度和心肌梗死面积. 结果: 益心舒胶囊可以降低MIRI大鼠血清中CK,LDH,AST和MDA含量,改善血液黏度,并可减少心肌梗死面积. 结论: 益心舒胶囊对大鼠MIRI具有明显的保护作用.
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| 关 键 词： | 益心舒胶囊 心肌缺血再灌注损伤 SD大鼠 |
| 收稿时间： | 2012/11/7 0:00:00 |
Protective effect of Yixinshu capsule on myocardial ischemia reperfusion injury in rats |
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| LIU Jia-wen,LIU Xin-yi,LI Jian-he,XIANG Da-xiong,YI Li-dan,HU Xiong-bin and YE Zu-guang.Protective effect of Yixinshu capsule on myocardial ischemia reperfusion injury in rats[J].China Journal of Chinese Materia Medica,2013,38(12):2005-2008. |
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| Authors: | LIU Jia-wen LIU Xin-yi LI Jian-he XIANG Da-xiong YI Li-dan HU Xiong-bin and YE Zu-guang |
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| Institution: | Key Research Laboratory for Development of New Drugs, The Second Xiangya Hospital of Central South University, Changsha 410013, China;Key Research Laboratory for Development of New Drugs, The Second Xiangya Hospital of Central South University, Changsha 410013, China;Key Research Laboratory for Development of New Drugs, The Second Xiangya Hospital of Central South University, Changsha 410013, China;Key Research Laboratory for Development of New Drugs, The Second Xiangya Hospital of Central South University, Changsha 410013, China;Key Research Laboratory for Development of New Drugs, The Second Xiangya Hospital of Central South University, Changsha 410013, China;Key Research Laboratory for Development of New Drugs, The Second Xiangya Hospital of Central South University, Changsha 410013, China;China Academy of Chinese Medical Sciences, Beijing 100700, China |
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| Abstract: | Objective: To observe the protective effect of Yixinshu capsule on myocardial ischemia reperfusion injury(MIRI) in SD rats. Method: Sixty healthy SD rats were randomized into six groups: sham group, MIRI model group, Xinsuning capsule group, low, middle or high dose Yixinshu capsule. Acute MIRI rat models were created by reperfusion for 120 min after anterior interventricular branch of the left coronary artery for 30 min. The serum creatine kinase (CK), lactic dehydrogenase (LDH), aspartate aminotransferase(AST) and malondialdehyde(MDA), blood viscosity, and infarction area of myocardium were determined. Result: Yixinshu capsule could reduce serum CK, LDH, AST and LDH activity, improve the blood viscosity, and reduced the myocardial infarct size. Conclusion: Yixinshu capsule can protect against MIRI in rats. |
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| Keywords: | Yixinshu capsule myocardial ischemia reperfusion injury SD rats |
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