| 基于生物药剂学性质的中药组分相似性分析方法的建立 |
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| 引用本文： | 郁丹红,贾晓斌. 基于生物药剂学性质的中药组分相似性分析方法的建立[J]. 中国中药杂志, 2013, 38(12): 1847-1850 |
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| 作者姓名： | 郁丹红 贾晓斌 |
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| 作者单位： | 江苏省中医药研究院 国家中医药管理局中药释药系统重点研究室, 江苏 南京 210028;南京中医药大学, 江苏 南京 210046;江苏省中医药研究院 国家中医药管理局中药释药系统重点研究室, 江苏 南京 210028;南京中医药大学, 江苏 南京 210046 |
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| 基金项目： | 国家"十一五"科技支撑计划项目(2008BAI51B03);江苏省中医药领军人才项目(2006) |
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| 摘 要： | 中药组分是一个复杂的多成分体系,如何表征和评价其多样的性质一直是中药现代化进程中亟待解决的关键科学问题.该文根据生物药剂学性质的相关规定,制定中药组分相似性评价标准,同时基于向量夹角余弦(cosine)和格鲁布斯(Grubbs)法建立相似性分析的方法,用于评价组分内代表性成分性质的离散程度,最终为中药组分亚组分的分类以及组分性质的整体性评价提供思路和方法.
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| 关 键 词： | 中药组分 生物药剂学性质 相似性分析 cosine法 Grubbs法 亚组分 |
| 收稿时间： | 2013-01-31 |
Construction of analytical method for similarity of traditional Chinese medicine components on the basis of biopharmaceutic properties |
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| YU Dan-hong and JIA Xiao-bin. Construction of analytical method for similarity of traditional Chinese medicine components on the basis of biopharmaceutic properties[J]. China Journal of Chinese Materia Medica, 2013, 38(12): 1847-1850 |
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| Authors: | YU Dan-hong and JIA Xiao-bin |
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| Affiliation: | Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Nanjing University of Chinese Medicine, Nanjing 210046, China;Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Nanjing University of Chinese Medicine, Nanjing 210046, China |
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| Abstract: | Traditional Chinese medicine components are a complex multi-component system. How to characterize and evaluate their diverse properties have long been key scientific problems in the modernization process of traditional Chinese medicines. According to the relevant regulations for biopharmaceutical properties, we made the criteria for evaluating similarity of Chinese medicine components, while establish an analytical method based on cosine and Grubbs to evaluate the dispersion degree of properties of representative components, so as to provide ideas and methods for classifying traditional Chinese medicine sub-components and evaluating the integrity of component properties. |
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| Keywords: | traditional Chinese medicine component biopharmaceutic property analysis on similarity cosine Grubbs sub-component |
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