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A Family-Based Analysis of the Association of the Dopamine D2 Receptor (DRD2) with Alcoholism |
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| Authors: | Howard J. Edenberg Tatiana Foroud Daniel L. Koller Alison Goate John Rice Paul Van Eerdewegh Theodore Reich C. Robert Cloninger John I. Nurnberger Jr Maria Kowalczuk Bo Wu T.-K. Li P. M. Conneally Jay A. Tischfield William Wu Shantia Shears Raymond Crowe Victor Hesselbrock Marc Schuckit Bernice Porjesz Henri Begleiter |
| Affiliation: | Indiana University School of Medicine (H.J.E., T.F., D.L.K., J.I.N.Jr., M.K., B.W., T.-K.L., P.M.C., J.A.T.), Indianapolis, Indiana;Washington University School of Medicine (A.G., J.R., P.V.E., T.R., C.R.C., W.W., S.S.), St. Louis, Missouri;University of Iowa School of Medicine (R.C.), Iowa City, Iowa;University of Connecticut School of Medicine (V.H.), Farming-ton, Connecticut;University of California at San Diego School of Medicine (M.S.), La Jolla, California;and SUNY Health Science Center at Brooklyn (B.P., H.B.), Brooklyn, New York. |
| Abstract: | The possible association of the DRD2 locus, and in particular the 7aql-A1 allele, with alcoholism remains controversial, in part because of differences in allele frequencies among populations. To avoid problems associated with differences in allele frequencies in different populations, we tested whether the DRD2 locus is associated with alcohol dependence in a large family-based sample. Neither the transmission/disequilibrium test nor the Affected Family-Based Controls test provide any evidence of linkage or association between the DRD2 locus and alcohol dependence. |
| Keywords: | Alcoholism Dopamine D2 Receptor Association Study Family Study |