| Effect of recombinant human epidermal growth factor on porcine partial-thickness wound healing |
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| 引用本文： | 戴方平,潘耀良,范青源,李永林,唐洪泰,俞为荣,韦多,陈玉林,葛绳德. Effect of recombinant human epidermal growth factor on porcine partial-thickness wound healing[J]. 中国人民解放军军医大学学报, 1997, 0(1) |
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| 作者姓名： | 戴方平 潘耀良 范青源 李永林 唐洪泰 俞为荣 韦多 陈玉林 葛绳德 |
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| 作者单位： | Burn Center，Changhai Hospital，Second Military Medical Unlverslty，Shanghai，200433 |
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| 摘 要： | Woundhealingisacomplexbiologicaleventinvolvinginflammation,cellularproliferationandmaturation.Growthfactorsareimplicatedasmes-sengersinwoundhealing.Thedevelopmentofre-combinantDNAtechnologymakesitpossibletogetlarge-scaleproductionofgrowthfactorsaswellasperformmoreextensiveexperimentsoninvivoresponsesofgrowthfactorsonwoundhealing['3].Recombinanthumanepidermalgrowthfactor(rh-EGF)isnotmuchamitogenicagentforhumankeratinocyteandfibroblastinvitro,butalsoacandidateinthecontrolofproliferationanddiff…
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Effect of recombinant human epidermal growth factor on porcine partial-thickness wound healing |
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| Dai Fangping, Pan Yaoliang, Fan Qingyuan, Li Yonglin, Tang Hongtai, Yu Weirong, Wei Duo, Chen Yulin, Ge Shengde. Effect of recombinant human epidermal growth factor on porcine partial-thickness wound healing[J]. Journal of Medical Colleges of PLA(China), 1997, 0(1) |
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| Authors: | Dai Fangping Pan Yaoliang Fan Qingyuan Li Yonglin Tang Hongtai Yu Weirong Wei Duo Chen Yulin Ge Shengde |
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| Abstract: | Wound healing is a complex biologic event. Numerous growth factors are involved in the regulation of tissue repair and remodelling processes. In this study, several techniques were used to observe the effects of recombinant human epidermal growth factors (rh-EGF) on porcine partial-thickness burn wound healing. Healing rates of the burn wounds were quantitated by computer image analysis of the wound Pkotographs. Biopsies were taken for examining the cell DNA cycle by flow cytometry, and for observing the keratinocyte migration and degree of reepithelialization quantitated by anti-keratin antibodies. The results indicated that daily topical application of rh-EGF in suitable concentrations accelerated epithelial healing of partial-thickness burn wounds, and there was also a dose-dependent effect of rh-EGF on healing rates of the partial-thickness burn wounds. |
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| Keywords: | epidermal growth factors DNA cycle analysis antibodies to keratin burn wound healing |
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