| 碱性成纤维细胞生长因子、纤维连接蛋白在肺炎支原体感染中的临床意义 |
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| 引用本文： | 陈艺坛,潘云虎,李华良,黄芳芳,陈光,熊勇.碱性成纤维细胞生长因子、纤维连接蛋白在肺炎支原体感染中的临床意义[J].临床肺科杂志,2010,15(5):645-646. |
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| 作者姓名： | 陈艺坛 潘云虎 李华良 黄芳芳 陈光 熊勇 |
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| 作者单位： | 南平,解放军第九二医院呼吸科,福建,353000 |
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| 基金项目： | 南京军区基金课题(08MA066) |
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| 摘 要： | 目的探讨碱性成纤维细胞生长因子(bFGF)、纤维连接蛋白(FN)在肺炎支原体感染患者中的临床意义。方法对我院2007年1月～2009年6月108例慢性咳嗽患者行支气管肺泡灌洗液(BALF)肺炎支原体-聚合酶链反应(PCR)检测。根据检测结果,分为实验组72例(肺炎支原体阳性)与对照组36例(肺炎支原体阴性)。对两组患者进行支气管镜肺活检,通过酶联免疫吸附试验(ELISA)方法检测bFGF水平,Western blot方法检测FN水平。结果肺炎支原体感染组bFGF及FN水平明显高于对照组,差异有统计学意义(P0.05)。结论肺炎支原体肺部感染可使肺组织bFGF水平增加,而bFGF可进一步诱导FN表达增加。bFGF、FN检测对肺炎支原体所致肺间质纤维化患者早期诊断、病情动态变化、治疗有一定的参考价值。
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| 关 键 词： | 肺炎支原体 肺间质纤维化 碱性成纤维细胞生长因子 酶联免疫吸附试验 蛋白质印迹 |
The clinical value of determination of basic fibroblast growth factor and fibronectin in patients infected with mycoplasma pneumoniae |
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| CHEN Yi-tan,PAN Yun-hu,LI Hua-liang,HUANG Fang-fang,CHEN Guang,XIONG Yong.The clinical value of determination of basic fibroblast growth factor and fibronectin in patients infected with mycoplasma pneumoniae[J].Journal of Clinical Pulmonary Medicine,2010,15(5):645-646. |
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| Authors: | CHEN Yi-tan PAN Yun-hu LI Hua-liang HUANG Fang-fang CHEN Guang XIONG Yong |
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| Institution: | CHEN Yi-tan,PAN Yun-hu,LI Hua-liang,HUANG Fang-fang,CHEN Guang,XIONG Yong.Respiratory Department,the 92nd Hospital of Nanping,Fujian Province,Nanping 353000,China |
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| Abstract: | Objective To explore the clinical value of determination of basic fibroblast growth factor(bFGF)and fibronectin(FN)in patients infected with mycoplasma pneumoniae.Methods 108 patients of chronic cough were detected mycoplasma pneumoniae used by polymerase chain reaction(PCR)in bronchial lavage fluid(BALF).All patients were divided into an experimental group(mycoplasma pneumoniae-positive)and a control group(Mycoplasma pneumoniae negative).Basic fibroblast growth factor(bFGF)and fibronectin(FN)were detected ... |
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| Keywords: | mycoplasma pneumoniae pulmonary interstitial fibros basic fibroblast growth factor ELSIA western blotNSE CEA |
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