| 小柴胡汤对大鼠脑中单胺类神经递质含量的影响 |
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| 引用本文： | 吴春福,胡茁,刘雯,于庆海.小柴胡汤对大鼠脑中单胺类神经递质含量的影响[J].中药药理与临床,1992(1). |
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| 作者姓名： | 吴春福 胡茁 刘雯 于庆海 |
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| 作者单位： | 沈阳药学院中药药理教研室 沈阳110015
(吴春福，胡茁，刘雯)，沈阳药学院中药药理教研室 沈阳110015(于庆海) |
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| 摘 要： | 应用高效液相色谱电化学检测方法测定了小柴胡汤对大鼠不同脑区单胺类神经递质及其代谢产物含量的影响。结果表明,小柴胡汤200mg/Kg,p o一天两次,给药7次可显著升高下丘脑DOPAC和5-HIAA的含量,降低下丘脑、大脑皮层中5-HT/5-HIAA比值和纹状体DA/DOPAC比值,提示小柴胡汤对上述脑区单胺类神经递质的更新率有一定促进作用。
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| 关 键 词： | 小柴胡汤 单胺类神经递质 下丘脑 大脑皮层 纹状体 |
Effect of Xiao Chai Hu Tang (XCHT) on the Contents of Monoamine Neurotransmitters in Rat Brain |
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| Wu Chunfu Hu Zuo Lui Wen Yu Qinghai.Effect of Xiao Chai Hu Tang (XCHT) on the Contents of Monoamine Neurotransmitters in Rat Brain[J].Pharmacology and Clinics of Chinese Materia Medica,1992(1). |
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| Authors: | Wu Chunfu Hu Zuo Lui Wen Yu Qinghai |
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| Abstract: | The effct of XCHT on the contents of monoamine neurotransmitters in discreted regions of rat brain was determined by using high performance layer chromatograph with electrochemical detection. The results show that XCHT 200 mg/kg p. o. two times daily for 7 times, significantly increase the content of 3 , 4-dihydroxypenzylacetic acid (DOPAC) and 5-hydroxyindonic acid (5-HIAA) in rat hypothalamus and decrease the ratio of ser~ otonin/5-HIAA in hypothalamus and cerebral cortex and the ratio of dopamine/DOPAC in striaum. The experimental results suggests that XCHT may have the promoting effect on the turnover of monoamine neurotansmitter in above regions of rat brain. |
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| Keywords: | Xiao Chai Hu Tang Monoamine Hypothalamus Cerebral cortex Str- iatum |
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