多巴胺联合美托洛尔对小儿肺炎合并心力衰竭的疗效及其对心肌酶的影响

目的:探讨联合使用多巴胺以及美托洛尔对小儿肺炎合并心力衰竭的临床疗效以及对心肌酶的影响作用.方法:选择2010年3月-2013年3月我院收治的小儿肺炎合并心力衰竭的患儿共104例,按照随机数字表法将其分治疗组和对照组,两组患儿均给予常规的综合治疗,治疗组在常规综合治疗的基础上加用多巴胺联合美托洛尔,观察2组患儿的疗效、临床症状以及治疗前后心肌酶的变化情况.结果:治疗组患儿总有效率为96.15%明显优于对照组80.77%(P<0.05);2组患儿治疗后心率、呼吸、血氧饱和度均较治疗前有明显的改善,与治疗前比较差异具有统计学意义(P<0.05);治疗后,治疗组与对照组相比较,心率,呼吸显著减慢(P均<0.05),血氧饱和度显著升高(P<0.05);2组患儿治疗后LDH、CK-MB水平均较治疗前有所降低,差异具有统计学意义(P<0.05);治疗后,治疗组患儿LDH、CK-MB水平均较对照组显著降低(P<0.05).结论:多巴胺联合美托洛尔治疗小儿肺炎合并心力衰竭能够取得较好的临床效果,同时改善患儿的临床症状以及心肌损伤,其安全性好,值得临床中进行推广运用.

Efficacy of dopamine combined with metoprolol on child pneumonia complicated with heart failure and their effects on myocardial enzyme

OBJECTIVE To study the efficacy of dopamine combined with metoprolol on child pneumonia complicated with heart failure and their effects on myocardial enzyme. METHODS From 2010 March to 2013 March, 104 cases of child pneumonia combined with heart failure were admitted to our hospital. By using the random number table method, all patients were divided into treatment group and control group. Patients in two groups were all provided with conventional therapy. The treatment group also received dopamine combined with metoprolol. Then patients of the two groups were compared for clinical symptoms before and after treatment and the changes of myocardial enzymes. RESULTS Patients in control group had a total effective rate of 80.77%, and in the treatment group 96.15%, with statistically significant differences (P<0.05). The heart rate, respiration, blood oxygen saturation in control group and the treatment group were all improved significantly (P<0.05). After treatment, compared with control group, the heart rate and respiration decreased significantly in treatment (P<0.05), blood oxygen saturation increased significantly (P<0.05). In both groups, LDH and CK-MB levels decreased significantly than those before treatment (P<0.05). After treatment, LDH and CK-MB levels in the treatment group were significantly lower than those in the control group (P<0.05).CONCLUSION Dopamine combined with metoprolol against child pneumonia complicated with heart failure can produce good clinical efficacy, alleviate clinical symptoms and myocardial injury. It has good safety, is worthy to be promoted in clinical practice.