The endogenous muscarinic acetylcholine receptor in Xenopus oocytes is of the M3 subtype |
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| Authors: | L A Van Wezenbeek J A Tonnaer G S Ruigt |
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| Institution: | CNS Pharmacology R&D Laboratory, Organon Int. B.V., Oss, The Netherlands. |
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| Abstract: | The muscarinic acetylcholine receptor of the Xenopus oocyte was characterized electrophysiologically. Iontophoretic responses to acetylcholine were inhibited by the muscarinic antagonists 4-DAMP, pirenzepine and AF-DX 116 at respective IC50 values of 7 nM, 15 microM and 2 microM. This antagonist sensitivity order indicates that the receptor is of the M3 muscarinic subtype. |
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