| 非酒精性脂肪肝患者血浆FGF21水平及与肥胖、胰岛素抵抗关系研究 |
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| 引用本文： | 周婷婷,秦波,郑天鹏,朱其荣,刘汉屈.非酒精性脂肪肝患者血浆FGF21水平及与肥胖、胰岛素抵抗关系研究[J].第三军医大学学报,2010,32(3). |
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| 作者姓名： | 周婷婷 秦波 郑天鹏 朱其荣 刘汉屈 |
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| 作者单位： | 1. 重庆医科大学附属第一医院感染科,重庆,400016
2. 重庆医科大学附属第二医院内分泌科,重庆,400010 |
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| 摘 要： | 目的探讨非酒精性脂肪肝(non-alcoholic fatty liver disease,NAFLD)患者血浆成纤维细胞生长因子21(fibroblast growth factor 21,FGF21)水平及与肥胖、胰岛素抵抗等因素的相关性。方法根据是否合并糖尿病将70例NAFLD患者分为单纯脂肪肝组36例和2型糖尿病合并脂肪肝组34例,正常对照组26例,采用酶联免疫分析法检测血浆FGF21水平,并测定空腹血糖(fasting plasma glucose,FPG)、空腹胰岛素(fasting insulin,FINS)、游离脂肪酸(free fattyacids,FFA)、血脂水平,以及体质量指数(body mass index,BMI)、腰臀比(waist-to-hipratio,WHR);采用稳态模型HOMA-IR和胰岛素敏感指数(insulin sensitivity index,ISI)评价胰岛素抵抗状态。结果①2组脂肪肝患者中,肥胖比例、BMI及WHR均显著高于正常对照组,甘油三酯(triglyceride,TG)、总胆固醇(total cholesterol,TC)、低密度脂蛋白胆固醇(low...
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| 关 键 词： | 非酒精性脂肪肝 成纤维细胞生长因子21 胰岛素抵抗 肥胖 |
Correlation between plasma fibroblast growth factor 21 level, obesity and insulin resistance in nonalcoholic fatty liver disease patients |
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| Zhou Tingting,Qin Bo,Zheng Tianpeng,Zhu Qirong,Liu Hanqu.Correlation between plasma fibroblast growth factor 21 level, obesity and insulin resistance in nonalcoholic fatty liver disease patients[J].Acta Academiae Medicinae Militaris Tertiae,2010,32(3). |
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| Authors: | Zhou Tingting Qin Bo Zheng Tianpeng Zhu Qirong Liu Hanqu |
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| Institution: | 1Department of Infectious Diseases;First Affiliated Hospital;Chongqing Medical University;Chongqing;400016;2Department of Endocrinology;Second Affiliated Hospital;400010;China |
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| Abstract: | Objective To investigate the correlation between plasma fibroblast growth factor 21(FGF21) level,obesity and insulin resistance(IR) in nonalcoholic fatty liver disease(NAFLD) patients.Methods Seventy NAFLD patients were divided into fatty liver(FL) group(n=36),type 2 diabetes complicated by fatty liver(DFL) group(n=34 cases),and normal control(NC) group(n=26) according to their complication of type 2 diabetics.Levels of plasma FGF21,fasting plasma glucose(FPG),fasting insulin(FINS),free fatty acid(FFA),lipi... |
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| Keywords: | nonalcoholic fatty liver fibroblast growth factor 21 insulin resistance obesity |
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