壳聚糖-海藻酸钠微囊对干扰素-tau的控释作用

目的用壳聚糖和海藻酸钠为原料,制备干扰素-tau微囊,希望开发成为一种口服干扰素制剂。方法使用注射器手工滴制的方法,在滴加过程中,速度和距离是影响囊形的主要因素。结果壳聚糖-海藻酸钠微囊法应用于干扰素-tau药物的包封,其制备简单快速,干扰素-tau包封率很高,并且具有肠溶缓释作用。结论壳聚糖-海藻酸钠微囊有望用作干扰素-tau或其它肽类药物的口服制剂。

Controlled release of interferon tau from chitosan-alginate microcapsules

Objective The microcapsules were prepared by using chitosan and sodium alginate as wall materials,and the controlled-release microcapsulas of interferon tau were hoped to be develop an oral interferon preparation.Methods The microcapsules were prepared by using syringe hand-made drop.In the process of dropping,speed and distance were the major factors which influence the form of microcapsules.Results Chitosanalginate microcapsules which was prepared simple and fast had high encapsulation rate and extended-release effect in intestine.Conclusion Chitosan-alginate microcapsules have the potential to be used to prepare interferon tau and other protein medicines.