Effect of PK 11195, an antagonist of benzodiazepine receptors, on platelet aggregation in a model of anxiety in the rat |
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| Authors: | J S Serrano A Hevia A Fernández-Alonso J R Castillo |
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| Affiliation: | Departamento de Farmacologia y Terapéutica, Facultad de Medicina, Sevilla, Spain. |
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| Abstract: | 1. Anxiety induced by forced swimming increases maximal intensity (h) of platelet aggregation (PAG) and time to reach it (t). 2. PK 11195 pretreatment (12.5 and 25 mg/kg) reverses anxiety-induced PAG changes. At 6.25 mg/kg it inhibits PAG. 3. Changes induced by anxiety on PAG may be mediated by peripheral-benzodiazepine receptors. |
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