| 温度敏感型液体栓塞材料的实验研究 |
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| 引用本文： | 盛希忠,刘作勤,李晓卫,刘文广,孔令斌,武乐斌,唐军,赵成如,王勤,王传栋. 温度敏感型液体栓塞材料的实验研究[J]. 山东大学学报(医学版), 2005, 43(7): 639-643 |
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| 作者姓名： | 盛希忠 刘作勤 李晓卫 刘文广 孔令斌 武乐斌 唐军 赵成如 王勤 王传栋 |
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| 作者单位： | 山东大学医学院,山东,济南,250012;山东省医学影像学研究所,山东,济南,250021;天津大学高分子材料研究所,天津,300072;山东省医疗器械研究所,山东,济南,250100 |
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| 基金项目： | 国家高技术研究发展计划（863计划）资助项目（2002AA326100）. |
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| 摘 要： | 目的：合成一种新型温度敏感性液体栓塞材料并探讨用于栓塞脑动静脉畸形（AVM）的可能性。方法：应用氮-异丙基丙烯酰胺（NIPAM）、氮-正丙基丙烯酰胺（NNPAM）和乙烯基己内酰胺（VC）合成共聚物，进行物理性质测定和体外AVM模型栓塞试验。结果：共聚物具有低临界溶解温度（LCST），具有水溶性和非粘附性特点，能成功栓塞体外AVM模型。结论：共聚物为一种脑AVM血管内栓塞治疗的新型液体栓塞材料，可用于进一步动物实验。
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| 关 键 词： | 温度敏感性共聚物 氮-异丙基丙烯酰胺 氮-正丙基丙烯酰胺 乙烯基己内酰胺 动静脉畸形 栓塞 |
| 文章编号： | 1671-7554（2005）07-0639-05 |
| 收稿时间： | 2004-12-20 |
| 修稿时间： | 2004-12-20 |
Laboratory study of a thermosensitive liquid embolic material |
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| SHENG Xi-zhong,LIU Zuo-qin,LI Xiao-wei,LIU Wen-guang,KONG Ling-bin,WU Le-bin,TANG Jun,ZHAO Cheng-ru,WANG Qin,WANG Chuan-dong. Laboratory study of a thermosensitive liquid embolic material[J]. Journal of Shandong University:Health Sciences, 2005, 43(7): 639-643 |
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| Authors: | SHENG Xi-zhong LIU Zuo-qin LI Xiao-wei LIU Wen-guang KONG Ling-bin WU Le-bin TANG Jun ZHAO Cheng-ru WANG Qin WANG Chuan-dong |
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| Abstract: | Objective:To synthesize a thermosensitive liquid embolic material and investigate it's embolic feasibility in cerebral arteriovenous malformations(AVM). Methods: The copolymer was synthesized with N;isopropylacrylamide(NIPAM) , N;n;propylacrylamide(NNPAM) and Vinyl caprolactam(VC), then it's properties were analyzed. The AVM models in vitro were embolized with the copolymer. Results:The copolymer has unique thermal behavior of lower critical soluble temperature (LCST), it is soluble in water and nonadhesive and could embolize the AVM models in vitro successfully. Conclusion:The copolymer is a new liquid embolic material for endovascular embolic treatment of AVM and may remain to be confirmed in further animal experiments. |
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| Keywords: | Thermosensitive copolymer N-isopropylacrylamide N-n-propylacrylamide Vinyl caprolactam Arteriovenous malformation Embolism |
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