| 峨嵋唐松草碱抗实验性心律失常作用 |
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| 引用本文： | 程绍瑜,刘玉芬,贾菊芳,钱家庆,辛文芬,莫长耕.峨嵋唐松草碱抗实验性心律失常作用[J].中国药理学通报,1988(4). |
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| 作者姓名： | 程绍瑜 刘玉芬 贾菊芳 钱家庆 辛文芬 莫长耕 |
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| 作者单位： | 同济医科大学药理教研室 武汉
(程绍瑜，刘玉芬，贾菊芳，钱家庆)，中国预防医学科学院劳动卫生与职业病研究所 北京
(辛文芬)，中国预防医学科学院劳动卫生与职业病研究所 北京(莫长耕) |
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| 摘 要： | 峨嵋唐松草碱10mg/kg,可以显著提高乌头碱诱发大鼠及哇巴因诱发豚鼠致心律失常用量;能明显地预防氯仿所致小鼠心室纤颤的发生;能显著对抗大鼠心肌缺血复灌引起的心律失常。峨嵋唐松草碱对大鼠心电图的影响,表现为显著的减慢大鼠心率,延长P—R及Q—Tc间期。
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| 关 键 词： | 峨嵋唐松草碱 乌头碱 哇巴因 心肌缺血 心律失常 复灌 |
PROTECTIVE EFFECTS OF METHOXYADIANTIFOLINE ON EXPERIMENTAL ARRHYTHMIAS |
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| Cheng Shaoyu,Liu Yufen & Jia Jufang et al.PROTECTIVE EFFECTS OF METHOXYADIANTIFOLINE ON EXPERIMENTAL ARRHYTHMIAS[J].Chinese Pharmacological Bulletin,1988(4). |
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| Authors: | Cheng Shaoyu Liu Yufen & Jia Jufang |
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| Abstract: | Methoxyadiantifoline 10 mg/kg i.v. significantly increased the arrhythmia- inducing dose of aconitine in anaesthetized rats, and that of ouabain in anaesthetized guinea pigs. It markedly prevented ventr icular fibrillation induced by chloroform. Methoxyadiantifoline is also effective in preventing reperfusion-induced arrhythmias in anaesthetized rats. It was demonstrated that methoxyadiantifoline slowed heart rate significantly, and prolonged P-R and Q-Tc interval of ECG in rats. |
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| Keywords: | Methoxyadiantifoline Aconitine Ouabain Arrhythmias Reperfusion Myocardil Ischemia |
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