STAT3和STAT5与Survivin和Ki67蛋白在鼻NK/T细胞淋巴瘤中的表达及意义

目的:研究STAT3和STAT5与Survivin和Ki67蛋白在EB病毒(EBV)相关鼻NK/T细胞淋巴瘤中的表达。方法:用免疫组织化学方法检测25例鼻NK/T细胞淋巴瘤患者病理标本STAT3、STAT5和Sur-vivin、Ki67的表达,并对它们的表达作相关性分析。另取20例慢性鼻窦炎患者的鼻腔黏膜作对照。结果:STAT3在鼻NK/T细胞淋巴瘤和慢性鼻窦炎中的阳性率分别为56%和10%;STAT5阳性率分别为68%和15%,均差异有统计学意义(均P<0.01)。Survivin在鼻NK/T细胞淋巴瘤和慢性鼻窦炎中的表达分别为68%和0;Ki67的表达分别为72%和20%,均差异有统计学意义(均P<0.01)。相关性分析发现STAT3的表达与Survivin和Ki67的表达均成正相关(r=0.428,P<0.05和r=0.704,P<0.01);STAT5的表达与Survivin和Ki67的表达无明显相关。结论:STAT通路可能在鼻NK/T细胞淋巴瘤的发生发展中起重要作用,STAT3可能通过诱导Survivin和Ki67的表达参与鼻NK/T细胞淋巴瘤的形成。

Expression and its significance of STAT3,STAT5, Survivin and Ki67 in nasal NK/T cell lymphoma

Objective:To study the expression and its significance of STAT3,STAT5,Survivin and Ki67 in the Epstein-Barr virus associated nasal NK/T cell lymphoma.Method:The expression of STAT3 , STAT5 ,Survivin and Ki67 were detected with immunohistochemistry in 25 cases of nasal NK/T cell lymphoma, and their relationship was analyzed. Nasal cavity tissues from 20 cases of chronic sinusitis were as the control group.Result:The positive rates of STAT3 in the lymphoma and in control group were 56% and 10%, respectively(P< 0.01 ).The positive rates of STAT5 in the lymphoma and in control group were 68% and 15%, respectively (P< 0.01 ). The positive rates of Survivin and Ki67 of nasal NK/T cell lymphoma were 68% and 72%, respectively; but it in the control group was 0% and 20%, respectively, P<0.01. The expression of STAT3 was positively related to that of Survivin and Ki67(r=0.428,P<0.05 and r=0.704,P<0.01);The expression of STAT5 was not related to that of Survivin and Ki67.Conclusion:The pathway of STAT may play a role in the development of nasal NK/T cell lymphoma.STAT maybe take part in the formation of nasal NK/T cell lymphoma through induction of Survivin and Ki67.