| 巴豆生物碱对人胃癌细胞SGC-7901的诱导分化作用研究 |
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| 引用本文： | 赵凤鸣,许冬青,王明艳,顾海,耿洁.巴豆生物碱对人胃癌细胞SGC-7901的诱导分化作用研究[J].中华中医药学刊,2005,23(1):134. |
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| 作者姓名： | 赵凤鸣 许冬青 王明艳 顾海 耿洁 |
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| 作者单位： | 南京中医药大学基础医学院,南京,210029 |
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| 基金项目： | 江苏省教育厅科研项目，江苏省重点实验室基金 |
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| 摘 要： | 以人胃癌细胞SGC-7901为研究材料,胃细胞分化标志酶碱性磷酸酶(ALP)和乳酸脱氢酶(LDH)为实验指标,观察人胃癌细胞SGC-7901在含有不同剂量巴豆生物碱培养液中的生长情况,结果发现经不同剂量巴豆生物碱处理的细胞,其碱性磷酸酶(ALP)和乳酸脱氢酶(LDH)的活力显著低于培养相同天数而未用巴豆生物碱处理的对照胃癌细胞,显示了巴豆生物碱对胃癌细胞具有诱导分化作用.
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| 关 键 词： | 巴豆生物碱 人胃癌细胞SGC-7901 诱导分化 |
| 文章编号： | 1009-5276(2005)01-0134-02 |
| 修稿时间： | 2003年9月10日 |
Studies On Croton Alkaloid (CA) Inducing Differentiation Of Human Grastric Cancer Cells SGC- 7901 |
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| ZHAO Feng ming,XU Dong qing,WANG Ming yan,GU Hai,GENG Jie.Studies On Croton Alkaloid (CA) Inducing Differentiation Of Human Grastric Cancer Cells SGC- 7901[J].Chinese Archives of Traditional Chinese Medicine,2005,23(1):134. |
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| Authors: | ZHAO Feng ming XU Dong qing WANG Ming yan GU Hai GENG Jie |
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| Abstract: | With human grastric cancer cells SGC-7901 as material,ALP and LDH as index,the influence ont he differentiation of SGC-7901 cells of the different concertration fo CA was investigated.The results showed that the activities of ALP nd LDH in the cells treated with different concertrations of CA were more lower than the control group.The conclusion was drawn that CA can induce the differentiation of grastric cancer cells. |
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| Keywords: | Croton Alkaloid Human Grastric Cancer Cells SGC-7901 Induce Differentiation |
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