Preeclampsia: a view through the danger model |
| |
| Institution: | 1. Implantation and Placental Development Laboratory, Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, VIC, Australia;2. Department of Molecular and Translational Science, Monash University, Clayton, VIC, Australia;3. Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, Australia;1. University of Mississippi Medical Center, Department of Pharmacology and Toxicology, Jackson, MS, United States;2. Emergency Medicine, Jackson, MS, United States;3. Obstetrics and Gynecology, Jackson, MS, United States;1. Department of Pharmacy Practice, College of Pharmacy, Oregon State University/Oregon Health & Science University, 3303, SW Bond Avenue, CH12C, Portland, OR 97239, USA;2. Center for Developmental Health, Oregon Health & Science University, Portland, OR 97239, USA;3. Department of Obstetrics & Gynecology, School of Medicine, Oregon Health & Science University, Portland, OR 97239, USA |
| |
| Abstract: | Classical thinking suggests that the immune system undergoes activation on the basis of discrimination between ‘self’ and ‘non-self’. Accordingly, the fetus activates the mother's immune system because the fetus is in part ‘non-self’. Thus, successful pregnancy depends on constraint of maternal immunity. Preeclampsia is an outcome of lost constraint.Instead, the danger model suggests that normal pregnancy, regardless of the expression of ‘non-self’ antigens, does not activate the maternal immune system unless that pregnancy expresses danger signals. Thus, preeclampsia stems from stress or abnormal cell death in pregnancy-related tissues. This compels expression of specific danger signals and potential activation of anti-fetal immunity, which secondarily feeds the syndrome.Study of preeclampsia from this perspective may bring forth novel mechanisms and indicators of vascular and metabolic dysfunction during pregnancy. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
