Relative clinical utility of simultaneous 18F-fluorodeoxyglucose PET/MRI and PET/CT for preoperative cervical cancer diagnosis |
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Authors: | Jing Gong Honghong Liu Zhaoliang Bao Lihua Bian Xiuzhen Li Yuanguang Meng |
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Affiliation: | 1.Department of Obstetrics and Gynecology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China; 2.Department of Nuclear Medicine, The First Medical Center of Chinese PLA General Hospital, Beijing, China; 3.Department of Obstetrics and Gynecology, The First Medical Center of Chinese PLA General Hospital, Beijing, China; 4.Department of Obstetrics and Gynecology, People’s Hospital of Shuangluan District, Chengde City, Hebei Province, China |
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Abstract: | ObjectiveTo investigate the utility of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/magnetic resonance imaging (PET/MRI) for the preoperative diagnosis of cervical cancer.MethodsWe retrospectively analyzed 114 patients who were diagnosed with cervical cancer and underwent PET/MRI (n = 59) or PET/computed tomography (PET/CT) (n = 65) before surgery. The maximal standardized uptake value (SUVmax) and mean SUV (SUVmean) were determined for regions of interest in the resultant radiographic images.ResultsRelative to PET/CT, 18F-FDG PET/MRI exhibited higher specificity and sensitivity in defining the primary tumor bounds and higher sensitivity for detection of bladder involvement. The SUVmax and SUVmean of PET/MRI were remarkably higher than those of PET/CT as a means of detecting primary tumors, bladder involvement, and the lymph node status. However, no significant differences in these values were detected when comparing the two imaging approaches as a means of detecting vaginal involvement or para-aortic lymph node metastasis.ConclusionsThese outcomes may demonstrate the capability of 18F-FDG PET/MRI to clarify preoperative cervical cancer diagnoses in the context of unclear PET/CT findings. However, studies directly comparing SUVs in different lesion types from patients who have undergone both PET/MRI and PET/CT scans are essential to validate and expand upon these findings. |
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Keywords: | 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging positron emission tomography/computed tomography cervical cancer preoperative diagnosis clinical application standardized uptake value |
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