藏族女性青少年血清钙磷及骨代谢生化标志物水平检测结果分析

目的了解藏族女性青少年血清钙、磷及骨代谢生化标志物水平,为藏族青少年生长发育研究提供相应资料。方法采用分层整群抽样方法,从拉萨市和那曲地区中小学生中抽取12～18岁藏族健康女性青少年336名,检测血清钙(Ca)、磷(P)、碱性磷酸酶(ALP)、骨性碱性磷酸酶(BAP)、骨钙素(BGP)水平。结果藏族女性青少年血清钙与年龄不相关(P>0.05),但拉萨地区明显高于那曲地区(P<0.05)。血清P,ALP,BAP,BGP水平与年龄均呈负相关(P值均<0.01),且各指标在多数年龄组表现为拉萨地区明显高于那曲地区(P值均<0.05)。除血清钙外,其他指标之间呈显著正相关(P值均<0.01)。结论藏族女性青少年血清钙、磷及骨代谢生化标志物水平随着年龄的增加、居住地海拔高度的增加,各指标水平逐渐降低。

The levels of serum total calcium, phosphate and biochemical markers of bone turnover in Tibetan female adolescents

Objective To study the change of serum total calcium(Ca),phosphate(P)and markers of bone turnover levels in Tibetan female adolescents,and to provide reference for the related researchs.Methods Using a stratified-multi-steps-cluster sampling method,336 health girls aged 12-18 years were selected from Lasa and Naqu to test the levels of serum Ca,P,alkaline phosphatase(ALP),bone alkaline phosphatase(BAP)and bone-gla-protein(BGP).Results No correlation was observed between Ca and age in Tibetan female adolescents,but Ca levels of Lasa girls were higher than those of Naqu(P<0.05).The levels of P,ALP,BAP and BGP had a negative correlation with age(P<0.01),and positive correlations were observed between them(P<0.05).The serum P,ALP,BAP and BGP levels of Lasa were significantly higher than those of Naqu in most age groups(P<0.01).Conclusion Metabolism of calcium,phosphate and biochemical makers of bone turnover in Tibetan female adolescents maybe decreased by the increasing of age and the different geographical conditions.