| 参芪复方对糖尿病大血管病变GK大鼠PI3-K/Akt信号通路的影响 |
| |
| 引用本文： | 高泓,谢春光,刘桠,陈敏,庄灿.参芪复方对糖尿病大血管病变GK大鼠PI3-K/Akt信号通路的影响[J].中医杂志,2011,52(1):49-53. |
| |
| 作者姓名： | 高泓 谢春光 刘桠 陈敏 庄灿 |
| |
| 作者单位： | 1. 成部中医药大学附属医院,四川省成都市十二桥路,39号,610075
2. 成都中医药大学 |
| |
| 基金项目： | 国家自然科学基金资助项目 |
| |
| 摘 要： | 目的探讨参芪复方防治糖尿病大血管病变的作用机制。方法以Wistar大鼠18只作为空白组,73只GK大鼠随机分为4组:GK组18只、模型组19只、阿托伐他汀组18只、参芪复方组18只。模型组、阿托伐他汀组、参芪复方组给予一氧化氮合酶(NOS)抑制剂L-NAME0.1mg/(ml.d),加入饮用水中进行糖尿病大血管病变造模,造模同时开始给药。35天后观测主动脉形态,检测血清C反应蛋白(CRP)含量和腹主动脉PI3-KP85a、AktmRNA表达量变化情况。结果参芪复方中药可减轻模型大鼠动脉粥样硬化的病理改变程度,降低血清CRP水平(P<0.01);参芪复方组PI3-KP85amRNA表达水平低于模型组,但无统计学意义;与模型组比较,参芪复方组能明显降低腹主动脉血管壁AktmRNA表达水平(P<0.01)。结论参芪复方可有效防治糖尿病大血管病变的发生发展,其机制可能与抑制糖尿病GK大鼠主动脉血管壁AktmRNA表达量,抑制PI3-K/Akt信号通路有关。
|
| 关 键 词： | 参芪复方 糖尿病大血管病变 PI3-K/Akt信号通路 AktmRNA表达量 |
Effect of Shenqi Compound Extract on PI3-K/Akt Signal Transduction of GK Rats with Diabetes Mellitus Macroangiopathy |
| |
| GAO Hong,XIE Chunguang,LIU Ya,CHEN Min,ZHUANG Can.Effect of Shenqi Compound Extract on PI3-K/Akt Signal Transduction of GK Rats with Diabetes Mellitus Macroangiopathy[J].Journal of Traditional Chinese Medicine,2011,52(1):49-53. |
| |
| Authors: | GAO Hong XIE Chunguang LIU Ya CHEN Min ZHUANG Can |
| |
| Institution: | GAO Hong1,XIE Chunguang1,LIU Ya2,CHEN Min2,ZHUANG Can2(1.Affiliated Hospital,Chengdu University of Chinese Medicine,Chengdu 610075,2.Chengdu University of Chinese Medicine) |
| |
| Abstract: | Objective To observe the influence of Shenqi Compound Extract (Compound extract of Ginseng and Astragalus membranaceus) on GK rats with diabetes mellitus macroangiopathy and its mechanism.Methods Eighteen Wistar rats were included in the control group,while the 73 GK rats were randomized into four groups:18 ones in the GK group,19 in the model group,18 in the atorvastatin group,and 18 in the Shenqi Compound Extract group.The model group,the atorvastatin group,and the Shenqi Compound Extract group were made ... |
| |
| Keywords: | Shenqi Compound Extract (Compound extract of Ginseng and Astragalus membranaceus) diabetes mellitus macroangiopathy PI3-K/Akt signal transduction Akt mRNA expression |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
