6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase expression in rat brain during development |
| |
| Authors: | Goren N Manzano A Riera L Ambrosio S Ventura F Bartrons R |
| |
| Affiliation: | Cátedra de Farmacología, Facultad de Odontología, Universidad de Buenos Aires, CEFYBO-CONICET, Buenos Aires, Argentina. |
| |
| Abstract: | This study reports the expression of the ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene (PFKFB3) (PFK-2/FBPase-2) in different stages of rat brain development. Northern blot and RT-PCR analysis demonstrated that ubiquitous PFK-2/FBPase-2 is expressed in rat brain from embryonic to adult life and shows a transient increase 1 day before birth, coincident with the maximum concentration of Fru-2,6-P(2) and PFK-2 activity. The levels of brain PFK-2/FBPase-2 gene expression as well as the enzymatic activity and the concentration of Fru-2,6-P(2) appear to be remarkably constant during adult life, without significant differences in the brain hippocampus, cortex, cerebellum or striatum areas. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
