Lack of modulation effects of praziquantel on DMN-induced lesion development in the Syrian hamster liver. |
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Authors: | W Thamavit M A Moore S Ruchirawat N Ito |
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Institution: | Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand. |
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Abstract: | The effects of repeated praziquantel administration subsequent to dimethylnitrosamine (DMN) treatment of Syrian hamsters were investigated. The antihelminthic drug was given (200 mg/kg body wt. as a suspension in corn oil, by i.g. intubation) 11 times at 2 week intervals starting at week 4 after initial 20 mg/kg DMN i.p. injections at weeks 0 and 2. Sacrifice at week 28 revealed no differences in either hepatocellular or cholangiocellular lesion development between carcinogen-initiated groups with or without antihelminthic treatment. No lesions were observed in the praziquantel alone or untreated groups. The results thus indicate no promotion potential for praziquantel on nitrosamine-induced lesions in the hamster liver. |
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