| 脐血清体外对急性白血病病儿化疗后造血细胞增殖的影响 |
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| 引用本文： | 王同显,佟琳如,李延年. 脐血清体外对急性白血病病儿化疗后造血细胞增殖的影响[J]. 青岛大学医学院学报, 1999, 35(4): 268 |
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| 作者姓名： | 王同显 佟琳如 李延年 |
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| 作者单位： | 青岛市红十字会中心血站!青岛266071(王同显)，青岛医学院附属医院儿内科(佟琳如，李延年)，青岛医学院第二附属医院儿科(尹振尧) |
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| 摘 要： | ①目的 探讨脐血清体外对急性白血病化疗后骨髓抑制期造血细胞增殖的影响。②方法 采用体外粒单细胞集落形成单位（ＣＦＵ－ＧＭ）培养法，观察正常成人血清和脐血清，对正常造血细胞和急性白血病化疗后抑制期骨髓造血细胞增殖的影响。③结果 脐血清组的正常骨髓ＣＦＵ－ＧＭ 产率明显高于成人血清组（ｔ＝ ６．９９３，Ｐ＜０．０１），脐血清组的白血病化疗后骨髓ＣＦＵ－ＧＭ 产率亦高于成人血清组（ｔ＝ ３．０６０，Ｐ＜ ０．０５）。④结论 脐血清体外能促进正常骨髓和白血病化疗后抑制期骨髓造血细胞的增殖。
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| 关 键 词： | 胎血 造血干细胞 白血病 药物疗法 |
EFFECT OF CORD BLOOD SERUM ON EXPANSION OF HEMATOPOIETIC PROGENITOR CELLS IN CHILDREN WITH ACUTE LEUKEMIA AFTER CHEMOTHERAPY |
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| Wang Tongxian,Tong Linru,Li Yannian,et al Qingdao Red Cross Central Station,Qingdao . EFFECT OF CORD BLOOD SERUM ON EXPANSION OF HEMATOPOIETIC PROGENITOR CELLS IN CHILDREN WITH ACUTE LEUKEMIA AFTER CHEMOTHERAPY[J]. Acta Academiae Medicinae Qingdao Universitatis, 1999, 35(4): 268 |
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| Authors: | Wang Tongxian Tong Linru Li Yannian et al Qingdao Red Cross Central Station Qingdao |
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| Affiliation: | Wang Tongxian,Tong Linru,Li Yannian,et al Qingdao Red Cross Central Station,Qingdao 266071, |
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| Abstract: | Objective To explore the effect of cord blood(CB) serum on hematopoietic progenitor cells of patients with acute leukemia(AL) in period of post chemotherapeutic bone marrow suppression(PCBS). Methods In vitro CFU GM culturing was used to study the effect of adult serum and CB serum on hemapoietic progenitor cells of normal bone marrow(BM) and children with AL in period of PCBS. Results CFU GM yield of normal BM and BM from children with AL in period of PCBS in CB serum group was significantly higher than that of adult serum group( t=3.060,P<0.05;t=6.993,P< 0.01). Conclusion CB serum could stimulate expansion of progenitor cells derived from normal BM and BM of patient with AL in period of PCBS.; |
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| Keywords: | fetal blood hematopoietic stem cells leukemia drug therapy |
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