新生儿高间接胆红素血症致病因素的Logistic回归分析

目的探讨新生儿早期高间接胆红素血症（高胆）与多种围产因素的关联性，找出相关的危险因素，为高胆的早期防治提供理论依据。方法对160例高胆患儿（病例组）与160例正常新生儿（对照组）的围产资料进行Logistic回归分析。结果多因素分析提示：胎膜早破、羊水粪染、胎儿窘迫或窒息、生后头3d体重下降〉10％、出生体重偏低、母妊娠期严重合并症（妊娠期高血压／妊娠期糖尿病／严重贫血等）、早产、头皮血肿、母产前使用催产素或镇静剂、剖宫产、高龄初产是新生儿高胆红素血症的主要危险因素，而产次、脐带绕颈、双胎或多胎等因素未显示出对高胆红素血症的明确影响。结论积极处理孕期疾病，严格掌握剖宫产指征，减少人为催产比例，加强高危妊娠、高危分娩的监测，积极喂养并及时处理新生儿并发症，可有效减少高胆红素血症的发生。

Newborn indirect hyperbilirubinemia pathogenic factors Logistic regression analysis

Objective ： On neonatal hyperbilirubinemia and perinatal factors of relevance to identify the risk factors for hyperbilirubinemia in the early to provide theoretical basis. Methods： 160 cases of children with biliary high （case group） and 160 cases of neonatal normal （control group） Perinatal information Logistic regression analysis. Results： Multivariate analysis showed that the results： premature rupture of membranes, meconium-stained amniotic fluid, fetal distress or birth asphyxia, the Health and the first 3 d weight loss 〉 10%, low birth weight, mother serious complications during pregnancy （gestational hypertension / Pregnancy Diabetes mellitus / severe anemia, etc. ）, premature birth, cephalhematoma, the mother of prenatal use of oxytocin or sedatives, cesarean section, senior citizens production early neonatal hyperbilirubinemia is the main risk factors, and parity, umbilical cord around the neck, twins or superfoetation such as fetal did not show on hyperbilirubinemia a clear impact. Conclusion： To deal with the disease during pregnancy actively, cesarean section strictly indications, reduce human proportion of oxytocin and strengthen high - risk pregnancy, high - risk maternity monitoring, and actively feeding and timely processing of neonatal complications, can be effective in reducing the occurrence of hyperbilirubinemia.