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In vitro studies on microphage functions in chronic pyoderma vegetans |
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| Authors: | D Djawari O P Hornstein |
| Institution: | (1) Department of Dermatology, University of Erlangen-Nürnberg, Hartmannstraße 14, D-8520 Erlangen, Germany |
| Abstract: | Summary The function of microphages has been studied in two patients with chronic pyoderma vegetans by in vitro determination of phagocytosis as well as chemotaxis. The results showed a striking decrease in the chemotactic activity of the neutrophil granulocytes, a reduced phagocytosis of Candida albicans and Staphylococcus aureus, and a weakness of the intracellular killing of these microorganisms. However, the NADH-dependent oxidase activity appeared to be intact. No defect was found in the specific cellular or humoral immune system in either patient.Supported by grant Dj2/2 of the Deutsche Forschungsgemeinschaft |
| Keywords: | Chronic pyoderma vegetans Defective microphage function Deficiency of the non-specific immune system Impairment of chemotaxis Defect of phagocytosis Weakened intracellular killing ability of neutrophil granulocytes |
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